Fetal growth restriction mice are more likely to exhibit depression‐like behaviors due to stress‐induced loss of dopaminergic neurons in the VTA
| Autor: | Meng-Xue Tian, Yu-Xi Wang, Jiajie Xi, Qiaoyi Sun, Ke Feng, Guiying Wang, Li Ma, Yukang Wu, Nana Liu, Wen Chen, Jiuhong Kang, Jianfeng Dong |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Dorsal Raphe Nucleus
Male 0301 basic medicine medicine.medical_specialty Receptors N-Methyl-D-Aspartate Biochemistry Midbrain Mice 03 medical and health sciences 0302 clinical medicine Dorsal raphe nucleus Memantine Internal medicine Genetics medicine Animals Molecular Biology Fetal Growth Retardation Depression business.industry Dopaminergic Neurons Ventral Tegmental Area Dopaminergic Glutamate receptor Antagonist Mice Inbred C57BL Ventral tegmental area 030104 developmental biology medicine.anatomical_structure Endocrinology nervous system NMDA receptor business Excitatory Amino Acid Antagonists Stress Psychological 030217 neurology & neurosurgery Biotechnology medicine.drug |
| Zdroj: | The FASEB Journal. 34:13257-13271 |
| ISSN: | 1530-6860 0892-6638 |
| Popis: | Fetal growth restriction (FGR) is a severe perinatal complication that can increase risk for mental illness. To investigate the mechanism by which FGR mice develop mental illness in adulthood, we established the FGR mouse model and the FGR mice did not display obvious depression-like behaviors, but after environmental stress exposure, FGR mice were more likely to exhibit depression-like behaviors than control mice. Moreover, FGR mice had significantly fewer dopaminergic neurons in the ventral tegmental area but no difference in serotoninergic neurons in the dorsal raphe. RNA-seq analysis showed that the downregulated genes in the midbrain of FGR mice were associated with many mental diseases and were especially involved in the regulation of NMDA-selective glutamate receptor (NMDAR) activity. Furthermore, the NMDAR antagonist memantine can relieve the stress-induced depression-like behaviors of FGR mice. In summary, our findings provide a theoretical basis for future research and treatment of FGR-related depression. |
| Databáze: | OpenAIRE |
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