Bullous pemphigoid and dipeptidyl peptidase-4 inhibitors: the importance of the pharmacotherapeutic history
| Autor: | Miguel Fernando García-Gil, Mar García García, Victoria Lezcano Biosca, Beatriz Aldea Manrique, Juan Monte Serrano |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Linagliptin 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Dermis Pemphigoid Bullous medicine Humans Hypoglycemic Agents Blood test Eosinophilia 030212 general & internal medicine Dipeptidyl peptidase-4 Aged 80 and over Dipeptidyl-Peptidase IV Inhibitors integumentary system medicine.diagnostic_test business.industry Blisters General Medicine medicine.disease Dermatology Serous fluid medicine.anatomical_structure Diabetes Mellitus Type 2 Abdomen Bullous pemphigoid medicine.symptom business |
| Zdroj: | Zaguán. Repositorio Digital de la Universidad de Zaragoza Consejo Superior de Investigaciones Científicas (CSIC) |
| ISSN: | 1469-0756 0032-5473 |
| Popis: | A 97-year-old man with a history of type II diabetes mellitus was treated with oral antidiabetic agents. He went to the emergency department after the appearance of blister-like itchy lesions on the abdomen and extremities since 2 months. The examination revealed eczematous lesions on the back, abdomen and extremities along with tense blisters on an erythematous base and serous content (figure 1A). In the blood test carried out, 285?mg/dL glucose and 7.1% eosinophilia stood out, with no associated leucocytosis or other relevant findings. Positive glycosuria (+++) was observed in urinalysis without other alterations. A skin biopsy was performed for histological and immunofluorescence studies that confirmed the diagnosis of bullous pemphigoid (figure 1B–D). Given the poor control of autoimmune blistering disease, possible triggers were looked for and linagliptin intake could be associated with the appearance of skin lesions 1?month earlier. ... |
| Databáze: | OpenAIRE |
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