Serum levels of vancomycin: is there a prediction using doses in mg/kg/day or m(2)/day for neonates?
| Autor: | Mariana Antunes Faria Lima, Tais Marina de Souza, Wanessa Trindade Clemente, Lêni Márcia Anchieta, Paulo Augusto Moreira Camargos, Juliana Chaves Abreu Fernandes, Roberta Maia de Castro Romanelli, Viviane Rosado |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Male Dose Staphylococcus 030106 microbiology lcsh:QR1-502 Gestational Age lcsh:Microbiology Drug Administration Schedule Statistics Nonparametric lcsh:Infectious and parasitic diseases Sepsis 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Predictive Value of Tests Reference Values Vancomycin 030225 pediatrics Statistical significance medicine Humans lcsh:RC109-216 Drug dosage calculations Retrospective Studies First episode Medicine(all) Dose-Response Relationship Drug business.industry Infant Newborn Gestational age Infant medicine.disease Newborn Anti-Bacterial Agents Infectious Diseases Anesthesia Cohort Linear Models Female Neonatal Sepsis business medicine.drug |
| Zdroj: | Brazilian Journal of Infectious Diseases v.20 n.5 2016 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Volume: 20, Issue: 5, Pages: 451-456, Published: OCT 2016 Brazilian Journal of Infectious Diseases, Vol 20, Iss 5, Pp 451-456 (2016) |
| ISSN: | 1678-4391 |
| Popis: | Coagulase-negative Staphylococcus has been identified as the main nosocomial agent of neonatal late-onset sepsis. However, based on the pharmacokinetics and erratic distribution of vancomycin, recommended empirical dose is not ideal, due to the inappropriate serum levels that have been measured in neonates. The aim of this study was to evaluate serum levels of vancomycin used in newborns and compare the prediction of adequate serum levels based on doses calculated according to mg/kg/day and m2/day. This is an observational reprospective cohort at a referral neonatal unit, from 2011 to 2013. Newborns treated with vancomycin for the first episode of late-onset sepsis were included. Total dose in mg/kg/day, dose/m2/day, age, weight, body surface and gestational age were identified as independent variables. For predictive analysis of adequate serum levels, multiple linear regressions were performed. The Receiver Operating Characteristic curve for proper serum vancomycin levels was also obtained. A total of 98 patients received 169 serum dosages of the drug, 41 (24.3%) of the doses had serum levels that were defined as appropriate. Doses prescribed in mg/kg/day and dose/m2/day predicted serum levels in only 9% and 4% of cases, respectively. Statistical significance was observed with higher doses when the serum levels were considered as appropriate (p |
| Databáze: | OpenAIRE |
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