Abnormal Default-Mode Network Homogeneity in Melancholic and Nonmelancholic Major Depressive Disorder at Rest
| Autor: | Huabing Li, Renzhi Huang, Guangrong Xie, Jingping Zhao, Meiqi Yan, Feng Liu, Wenbin Guo, Yanqing Tang, Xilong Cui, Jindong Chen |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Support Vector Machine Article Subject Rest Precuneus Prefrontal Cortex Neurosciences. Biological psychiatry. Neuropsychiatry Right angular gyrus Audiology Melancholic depression Sensitivity and Specificity behavioral disciplines and activities Diagnosis Differential Young Adult 03 medical and health sciences 0302 clinical medicine Parietal Lobe mental disorders medicine Humans Default mode network Psychiatric Status Rating Scales Depressive Disorder Depressive Disorder Major medicine.diagnostic_test business.industry Brain Default Mode Network Reproducibility of Results Medial frontal gyrus medicine.disease Magnetic Resonance Imaging Temporal Lobe Frontal Lobe 030227 psychiatry medicine.anatomical_structure Neurology Major depressive disorder Female Neurology (clinical) Left superior Functional magnetic resonance imaging business 030217 neurology & neurosurgery RC321-571 Research Article |
| Zdroj: | Neural Plasticity Neural Plasticity, Vol 2021 (2021) |
| ISSN: | 1687-5443 2090-5904 |
| DOI: | 10.1155/2021/6653309 |
| Popis: | Background. Melancholic depression has been assumed as a severe type of major depressive disorder (MDD). We aimed to explore if there were some distinctive alterations in melancholic MDD and whether the alterations could be used to discriminate the melancholic MDD and nonmelancholic MDD. Methods. Thirty-one outpatients with melancholic MDD, thirty-three outpatients with nonmelancholic MDD, and thirty-two age- and gender-matched healthy controls were recruited. All participants were scanned by resting-state functional magnetic resonance imaging (fMRI). Imaging data were analyzed with the network homogeneity (NH) and support vector machine (SVM) methods. Results. Both patient groups exhibited increased NH in the right PCC/precuneus and right angular gyrus and decreased NH in the right middle temporal gyrus compared with healthy controls. Compared with nonmelancholic patients and healthy controls, melancholic patients exhibited significantly increased NH in the bilateral superior medial frontal gyrus and decreased NH in the left inferior temporal gyrus. But merely for melancholic patients, the NH of the right middle temporal gyrus was negatively correlated with TEPS total and contextual anticipatory scores. SVM analysis showed that a combination of NH values in the left superior medial frontal gyrus and left inferior temporal gyrus could distinguish melancholic patients from nonmelancholic patients with accuracy, sensitivity, and specificity of 79.66% (47/59), 70.97% (22/31), and 89.29%(25/28), respectively. Conclusion. Our findings showed distinctive network homogeneity alterations in melancholic MDD which may be potential imaging markers to distinguish melancholic MDD and nonmelancholic MDD. |
| Databáze: | OpenAIRE |
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