Advanced carcinoma of the nasopharynx. A clinical study of 274 patients
| Autor: | James D. Cox, Ralph Mackintosh, Robert Middleton, Maimu Ohanian, Bernard Roswit, Camilo Paig, Zbigniew Petrovich, Y. Rao, J. A. del Regato, R. Byhardt |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty medicine.medical_treatment Gastroenterology Radiotherapy High-Energy Internal medicine medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Stage (cooking) Cobalt Radioisotopes Lymph node Aged Neoplasm Staging Performance status business.industry X-Rays Pharynx Nasopharyngeal Neoplasms Radiotherapy Dosage Middle Aged medicine.disease Prognosis Radiation therapy medicine.anatomical_structure Lymphatic system Nasopharyngeal carcinoma Lymphatic Metastasis Carcinoma Squamous Cell Female business |
| Zdroj: | Radiology. 144(4) |
| ISSN: | 0033-8419 |
| Popis: | A total of 274 patients with a diagnosis of nasopharyngeal carcinoma was treated in eight Veterans Administration Hospitals over a period of 22 years. Of the 274 patients, 256 (93%) had squamous-cell carcinoma, while 18 (7%) had other tumors. Most of the squamous-cell carcinoma patients (82%) had Stage IV disease; cervical lymph node metastases were found in 193 (75%), and distant metastases were present in 22 (9%). The actuarial 5-, 10-, and 15-year survival rates for the 256 squamous-cell carcinoma patients were 15%, 10%, and 7%, while they were 49%, 42%, and 35% for the 18 patients with other tumors (p = 0.006). There was a progressive decrease in 5-year survival with the increase in the stage of tumor. The survival of the 63 patients without metastases was better than the survival of the 193 patients with cervical metastases (24% vs. 12% at 5 years, p = 0.03). The presence of T4 disease or Initial Performance Status of less than 80 on the Karnofsky Scale indicated a poor prognosis (p = 0.0001). Treatment failure occurred in 83% of the patients by 2 years after therapy and was due to the lack of tumor control at the primary site. Advanced (N3) cervical lymph node metastases indicated that systemic tumor dissemination of the nasopharynx is an uncommon malignancy. |
| Databáze: | OpenAIRE |
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