In vitro activity of carvacrol, cinnamaldehyde and thymol combined with antifungals against Malassezia pachydermatis
| Autor: | Jânio Morais Santúrio, Carla Weiblen, Francielli Pantella Kunz de Jesus, Juliana S. M. Tondolo, Karine Bizzi Schlemmer, M.I. Azevedo, Sônia de Avila Botton, Vanessa S. Machado, Sydney Hartz Alves |
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| Rok vydání: | 2019 |
| Předmět: |
Antifungal Agents
Itraconazole Phytochemicals Microbial Sensitivity Tests Pharmacology 03 medical and health sciences chemistry.chemical_compound Dogs Drug Resistance Fungal medicine Animals Dermatomycoses Dog Diseases Acrolein Thymol 0303 health sciences Malassezia 030306 microbiology Chemistry Clotrimazole Antimicrobial Malassezia pachydermatis Drug Combinations Infectious Diseases Nystatin Cymenes Ketoconazole Miconazole medicine.drug |
| Zdroj: | Journal de Mycologie Médicale. 29:375-377 |
| ISSN: | 1156-5233 |
| DOI: | 10.1016/j.mycmed.2019.08.003 |
| Popis: | Malassezia pachydermatis is an important opportunistic agent of dermatitis and otitis in dogs. M. pachydermatis is generally treated with topical therapies using combinations of antifungal, antimicrobial and anti-inflammatory agents. We investigated the in vitro activities of carvacrol (CRV), cinnamaldehyde (CIN) and thymol (THY) alone and in combination with antifungal agents (fluconazole, itraconazole, ketoconazole, clotrimazole, miconazole, terbinafine and nystatin) against M. pachydermatis. The assays were performed according to the Clinical and Laboratory Standards Institute (CLSI), using Sabouraud dextrose broth and checkerboard microdilution. The mean fractional inhibitory concentration index (FICI) showed primary synergies for the combinations carvacrol + nystatin, thymol + nystatin, and carvacrol + miconazole (80%). In conclusion, the results obtained indicate that the phytochemicals tested showed relevant in vitro anti-M. pachydermatis activity. Future in vivo experiments are needed to elucidate the safety and therapeutic potential of these combinations. |
| Databáze: | OpenAIRE |
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