Comorbidity burden may explain adiponectin’s paradox as a marker of increased mortality risk in hemodialysis patients
| Autor: | Ramzia Abu Hamad, Amin Khatib, Ilia Beberashvili, Tamar Cohen-Cesla, Ada Azar, Kobi Stav, Shai Efrati |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Nephrology medicine.medical_specialty Science medicine.medical_treatment 030232 urology & nephrology Nutritional Status Adipokine Comorbidity 030204 cardiovascular system & hematology Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Renal Dialysis Internal medicine Prevalence Humans Medicine Survival rate Aged Aged 80 and over Inflammation Multidisciplinary Adiponectin business.industry Maintenance hemodialysis Middle Aged medicine.disease Survival Rate Oxidative Stress Cardiovascular Diseases Cohort Female Hemodialysis business Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-88558-0 |
| Popis: | Despite experimental evidence of beneficial metabolic, antiatherosclerotic and antiinflammatory effects of the 30 kDa adipokine, adiponectin, maintenance hemodialysis (MHD) patients with high adiponectin blood levels have paradoxically high mortality rates. We aimed to examine the direction of the associations between adiponectin and all-cause and cardiovascular mortality as well as with markers of oxidative stress, inflammation and nutrition in MHD patients with varying degrees of comorbidities. A cohort of 261 MHD patients (mean age 68.6 ± 13.6 years, 38.7% women), grouped according to baseline comorbidity index (CI) and serum adiponectin levels, were followed prospectively for six years. High and low concentrations were established according to median CI and adiponectin levels and cross-classified. Across the four CI-adiponectin categories, the group with low comorbidities and high adiponectin exhibited the best outcomes. Conversely, the high comorbidity group with high adiponectin levels had the lowest survival rate in both all-cause mortality (log rankχ2 = 23.74, p 2 = 34.16, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink