Prediction of Torsade de Pointes From the QT Interval: Analysis of a Case Series of Amisulpride Overdoses
| Autor: | Geoffrey K. Isbister, Carolyn V. Coulter, J. P. Joy, Stephen B. Duffull |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Adolescent Drug overdose Severity of Illness Index QT interval law.invention Electrocardiography Young Adult Torsades de Pointes law mental disorders medicine Humans Pharmacology (medical) Prospective Studies Amisulpride Pharmacology Series (stratigraphy) Clinical pharmacology Dose-Response Relationship Drug medicine.diagnostic_test business.industry Prolongation nutritional and metabolic diseases Middle Aged medicine.disease nervous system diseases Sulpiride poisoning Long QT Syndrome Anesthesia Female Drug Overdose Sulpiride business Antipsychotic Agents medicine.drug |
| Zdroj: | Clinical Pharmacology & Therapeutics. 90:243-245 |
| ISSN: | 1532-6535 0009-9236 |
| DOI: | 10.1038/clpt.2011.107 |
| Popis: | Electrocardiograms (ECGs) from a case series of 86 amisulpride overdose events in 66 patients were reviewed for abnormal QT intervals and torsade de pointes (TdP). Eight patients exhibited TdP. In this investigative case series, the magnitude of prolongation of the QT interval was a stronger predictor of TdP than the mere presence of a prolongation per se. Clinical Pharmacology & Therapeutics (2011) 90 2, 243–245. doi:10.1038/clpt.2011.107 |
| Databáze: | OpenAIRE |
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