A family study of Paget's disease of bone
| Autor: | A E Emery, S M Holloway, J A Sofaer |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Pathology Epidemiology Genes Recessive Disease Virus Genetic variation medicine Humans Family Occupations Family history Aged Genes Dominant business.industry Age Factors Public Health Environmental and Occupational Health Family aggregation Middle Aged Osteitis Deformans medicine.disease Dermatology Paget's disease of bone Social Class Etiology Female business Research Article |
| Zdroj: | Journal of Epidemiology & Community Health. 37:226-231 |
| ISSN: | 0143-005X |
| Popis: | Familial aggregation of Paget's disease of bone occurs occasionally and an exclusively genetic aetiology has been proposed in the past. On the other hand, epidemiological surveys point to an important environmental contribution, and evidence is accumulating to suggest that the disease may be caused by a slow virus infection. Analysis of 407 family history questionnaires completed by patients with Paget's disease confirmed the familial nature of the disease. Overall, the findings were consistent with the hypothesis that Paget's disease is caused by infection with a common and widespread virus superimposed on genetic variation for susceptibility and perhaps severity of the disease. |
| Databáze: | OpenAIRE |
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