Mitochondria in Cardiac Postconditioning
| Autor: | Saveria Femminò, Pasquale Pagliaro, Claudia Penna, Jasmin Popara |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Programmed cell death Physiology Mini Review Connexin Context (language use) 030204 cardiovascular system & hematology Mitochondrion lcsh:Physiology connexin 43 03 medical and health sciences 0302 clinical medicine Katp channels Physiology (medical) redox signaling reactive oxygen species Cardioprotection chemistry.chemical_classification Reactive oxygen species lcsh:QP1-981 Connexin 43 Ischemia/reperfusion Mitochondria Redox signaling ischemia/reperfusion Cell biology mitochondria 030104 developmental biology Mitochondrial permeability transition pore chemistry cardioprotection |
| Zdroj: | Frontiers in Physiology Frontiers in Physiology, Vol 9 (2018) |
| ISSN: | 1664-042X |
| Popis: | Mitochondria play a pivotal role in cardioprotection. Here we report some fundamental studies which considered the role of mitochondrial components (connexin 43, mitochondrial KATP channels and mitochondrial permeability transition pore) in postconditioning cardioprotection. We briefly discuss the role of mitochondria, reactive oxygen species and gaseous molecules in postconditioning. Also the effects of anesthetics - used as cardioprotective substances - is briefly considered in the context of postconditioning. The role of mitochondrial postconditioning signaling in determining the limitation of cell death is underpinned. Issues in clinical translation are briefly considered. The aim of the present mini-review is to discuss in a historical perspective the role of main mitochondria mechanisms in cardiac postconditioning. |
| Databáze: | OpenAIRE |
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