| Autor: |
Henriette Lorenzen, Morten Hanefeld Dziegiel, Grethe Risum Krog, Frederik Banch Clausen |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Krog, G R, Lorenzen, H, Clausen, F B & Dziegiel, M H 2023, ' Secretor status of blood group O mothers is associated with development of ABO haemolytic disease in the newborn ', Vox Sanguinis, vol. 118, no. 5, pp. 402-406 . https://doi.org/10.1111/vox.13420 |
| DOI: |
10.1111/vox.13420 |
| Popis: |
Background and Objectives: Identification of antibody characteristics and genetics underlying the development of maternal anti-A/B linked to inducing haemolytic disease of the foetus and newborn could contribute to the development of screening methods predicting pregnancies at risk with high diagnostic accuracy. Materials and Methods: We examined 73 samples from mothers to 37 newborns with haemolysis (cases) and 36 without (controls). The secretor status was determined by genotyping a single nucleotide polymorphism in FUT2, rs601338 (c.428G>A). Results: We found a significant association between secretor mothers and newborns developing haemolysis (p = 0.028). However, stratifying by the newborn's blood group, the association was found only in secretor mothers to blood group B newborns (p = 0.032). In fact, only secretor mothers were found in this group. By including antibody data from a previous study, we found higher median semi-quantitative levels of IgG1 and IgG3 among secretor mothers than non-secretor mothers to newborns with and without haemolysis. Conclusion: We found that the maternal secretor status is associated with the production of anti-A/B, pathogenic to ABO-incompatible newborns. We suggest that secretors experience hyper-immunizing events more frequently than non-secretors, leading to the production of pathogenic ABO antibodies, especially anti-B. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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