Erythrocyte Zinc Concentration in Patients with Subacute Thyroiditis
| Autor: | Kaoru Yoshinaga, Katsumi Yoshida, Yoshinori Kiso, T Watanabe, Hiroshi Fukazawa, Kazuro Kaise, Yamamoto M, Toshiro Sakurada, Nobuko Kaise |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Thyroid Hormones endocrine system medicine.medical_specialty Erythrocytes endocrine system diseases Prednisolone Endocrinology Diabetes and Metabolism Graves' disease Clinical Biochemistry Thyroid Function Tests Biochemistry Thyroid function tests Thyroiditis Endocrinology Internal medicine medicine Humans Thyroiditis Subacute Aged Subacute thyroiditis medicine.diagnostic_test business.industry Biochemistry (medical) Thyroid Middle Aged medicine.disease Graves Disease Zinc Red blood cell medicine.anatomical_structure Female business medicine.drug Hormone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 70:788-791 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | We have recently reported that red blood cell (RBC) zinc (Zn) in patients with hyperthyroidism reflects a patient's integrated thyroid hormone level over the previous few months. In the present paper RBC Zn concentrations were measured in 10 patients with subacute thyroiditis whose total plasma T4 and T3 levels were elevated. The values were compared with those obtained in 10 patients with untreated Graves' disease, whose plasma T4 concentrations were elevated to the same level as in the former group. The RBC Zn concentration was normal in 9 of 10 patients with subacute thyroiditis, but was depressed in all patients with Graves' disease. The mean (+/- SE) RBC Zn in patients with subacute thyroiditis was 162 +/- 9 mumol/L, significantly (P less than 0.001) higher than that in Graves' disease (87 +/- 5 mumol/L). During prednisolone treatment the RBC Zn in patients with subacute thyroiditis remained at the normal level and did not change significantly, although it was slightly decreased at 2 and 4 weeks of treatment. On the other hand, the RBC Zn in patients with Graves' disease was significantly increased at 8 weeks of treatment and reached the normal range in 12 weeks. These results suggest that elevation of plasma thyroid hormone concentrations in patients with subacute thyroiditis is transient and does not cause any significant change in the RBC Zn concentration. |
| Databáze: | OpenAIRE |
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