Serum tumor-associated autoantibodies as diagnostic biomarkers for lung cancer: A systematic review and meta-analysis

Autor: Jinliang Kong, Zhen-Ming Tang, Chun-Mei Wang, Yan-Bin Wu, Zhou-Gui Ling
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Pathology
Lung Neoplasms
Physiology
lcsh:Medicine
Diagnostic accuracy
Gastroenterology
Biochemistry
Lung and Intrathoracic Tumors
0302 clinical medicine
Mathematical and Statistical Techniques
Immune Physiology
Medicine and Health Sciences
Multiplex
Enzyme-Linked Immunoassays
lcsh:Science
Multidisciplinary
Immune System Proteins
Oncology
030220 oncology & carcinogenesis
Meta-analysis
Physical Sciences
Statistics (Mathematics)
Research Article
medicine.medical_specialty
Immunology
Research and Analysis Methods
Sensitivity and Specificity
Antibodies
03 medical and health sciences
Diagnostic Medicine
Internal medicine
medicine
Cancer Detection and Diagnosis
Biomarkers
Tumor
Diagnostic biomarker
Humans
In patient
Statistical Methods
Lung cancer
Immunoassays
Autoantibodies
Neoplasm Staging
business.industry
lcsh:R
Autoantibody
Biology and Life Sciences
Proteins
Cancers and Neoplasms
medicine.disease
Non-Small Cell Lung Cancer
030104 developmental biology
ROC Curve
Potential biomarkers
Immunologic Techniques
lcsh:Q
business
Publication Bias
Mathematics
Biomarkers
Meta-Analysis
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0182117 (2017)
ISSN: 1932-6203
Popis: Objective We performed a comprehensive review and meta-analysis to evaluate the diagnostic values of serum single and multiplex tumor-associated autoantibodies (TAAbs) in patients with lung cancer (LC). Methods We searched the MEDLINE and EMBASE databases for relevant studies investigating serum TAAbs for the diagnosis of LC. The primary outcomes included sensitivity, specificity and accuracy of the test. Results The systematic review and meta-analysis included 31 articles with single autoantibody and 39 with multiplex autoantibodies. Enzyme-linked immunosorbent assay (ELISA) was the most common detection method. For the diagnosis of patients with all stages and early-stage LC, different single or combinations of TAAbs demonstrated different diagnostic values. Although individual TAAbs showed low diagnostic sensitivity, the combination of multiplex autoantibodies offered relatively high sensitivity. For the meta-analysis of a same panel of autoantibodies in patients at all stages of LC, the pooled results of the panel of 6 TAAbs (p53, NY-ESO-1, CAGE, GBU4-5, Annexin 1 and SOX2) were: sensitivity 38% (95% CI 0.35–0.40), specificity 89% (95% CI 0.86–0.91), diagnostic accuracy 65.9% (range 62.5–81.8%), AUC 0.52 (0.48–0.57), while the summary estimates of 7 TAAbs (p53, CAGE, NY-ESO-1, GBU4-5, SOX2, MAGE A4 and Hu-D) were: sensitivity 47% (95% CI 0.34–0.60), specificity 90% (95% CI 0.89–0.92), diagnostic accuracy 78.4% (range 67.5–88.8%), AUC 0.90 (0.87–0.93). For the meta-analysis of the same panel of autoantibodies in patients at early-stage of LC, the sensitivities of both panels of 7 TAAbs and 6 TAAbs were 40% and 29.7%, while their specificities were 91% and 87%, respectively. Conclusions Serum single or combinations of multiplex autoantibodies can be used as a tool for the diagnosis of LC patients at all stages or early-stage, but the combination of multiplex autoantibodies shows a higher detection capacity; the diagnostic value of the panel of 7 TAAbs is higher than the panel of 6 TAAbs, which may be used as potential biomarkers for the early detection of LC.
Databáze: OpenAIRE
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