Maternal and child genetic liability for smoking and caffeine consumption and child mental health: an intergenerational genetic risk score analysis in the ALSPAC cohort
| Autor: | Elis Haan, Marcus R. Munafò, Hannah M Sallis, Robyn E Wootton, Laura Schellhas, Gemma C Sharp, Luisa Zuccolo, Kayleigh E Easey |
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| Rok vydání: | 2021 |
| Předmět: |
Longitudinal study
Offspring media_common.quotation_subject Mothers 030508 substance abuse Medicine (miscellaneous) Genome-wide association study Psychiatry Mental health ALSPAC caffeine genetic risk score intergenerational effects mental health tobacco genetic risk score tobacco Cohort Studies intergenerational effects 03 medical and health sciences 0302 clinical medicine Risk Factors Caffeine medicine Personality Humans Sensation seeking Longitudinal Studies 030212 general & internal medicine media_common caffeine 2. Zero hunger Pregnancy business.industry Smoking fungi ALSPAC medicine.disease Mental health 3. Good health Psychiatry and Mental health Mental Health Conduct disorder Cohort Polygenic risk score Female 0305 other medical science business 030217 neurology & neurosurgery mental health Genome-Wide Association Study Demography |
| Zdroj: | Schellhas, L, Haan, E, Easey, K E, Wootton, R E, Sallis, H M, Sharp, G C, Munafò, M R & Zuccolo, L 2021, ' Maternal and child genetic liability for smoking and caffeine consumption and child mental health : An intergenerational genetic risk score analysis in the ALSPAC cohort ', Addiction, vol. 116, no. 11, pp. 3153-3166 . https://doi.org/10.1111/add.15521 |
| ISSN: | 1360-0443 0965-2140 |
| Popis: | Background and aims Previous studies suggest an association between maternal tobacco and caffeine consumption during and outside of pregnancy and offspring mental health. We aimed to separate effects of the maternal environment (intrauterine or postnatal) from pleiotropic genetic effects. Design Secondary analysis of a longitudinal study. We 1) validated smoking and caffeine genetic risk scores (GRS) derived from published GWAS for use during pregnancy, 2) compared estimated effects of maternal and offspring GRS on childhood mental health outcomes, and 3) tested associations between maternal and offspring GRS on their respective outcomes. Setting We used data from a longitudinal birth cohort study from England, the Avon Longitudinal Study of Parents and Children (ALSPAC). Participants Our sample included 7921 mothers and 7964 offspring. Measurements Mental health and non-mental health phenotypes were derived from questionnaires and clinical assessments: 79 maternal phenotypes assessed during and outside of pregnancy, and 71 offspring phenotypes assessed in childhood ( Findings The maternal smoking and caffeine GRS were associated with maternal smoking and caffeine consumption during pregnancy (2nd trimester: Psmoking = 3.0×10−7, Pcaffeine = 3.28×10−5). Both the maternal and offspring smoking GRS showed evidence of association with reduced childhood anxiety symptoms (βmaternal = -0.033; βoffspring= -0.031) and increased conduct disorder symptoms (βmaternal= 0.024; βoffspring= 0.030), after correcting for multiple testing. Finally, the maternal and offspring smoking GRS were associated with phenotypes related to sensation seeking behaviours in mothers and adolescence (e.g., increased symptoms of externalising disorders, extraversion, and monotony avoidance). The caffeine GRS showed weaker evidence for associations with mental health outcomes. Conclusions We did not find strong evidence that maternal smoking and caffeine genetic risk scores (GRS) have a causal effect on offspring mental health outcomes. Our results confirm that the smoking GRS also captures liability for sensation seeking personality traits. |
| Databáze: | OpenAIRE |
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