Secretory phospholipase A2 in patients with coronary artery disease
| Autor: | Cirilo Pereira da Fonseca Neto, José Carlos Faria Garcia, Maria das Graças Carvalho, Luciana Moreira Lima, Marinez O. Sousa |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Coronary angiography
Adult Male medicine.medical_specialty Coronary Artery Disease Coronary Angiography Secretory Phospholipase A2 Atheromatosis Coronary artery disease Risk Factors Internal medicine medicine Humans In patient Prospective Studies Phospholipases A2 Secretory Aged Hematology business.industry Middle Aged medicine.disease Coronary arteries Stenosis medicine.anatomical_structure Cardiology Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Journal of thrombosis and thrombolysis. 29(3) |
| ISSN: | 1573-742X |
| Popis: | This study investigated the correlation of sPLA2 (secretory phospholipase A2) activity with the atheromatosis extent in subjects with coronary artery disease (CAD) undergoing coronary angiography. We analyzed 123 patients, including 35 subjects with angiographically normal coronary arteries (controls), 31 with mild/moderate atheromatosis (stenosis of 30-70% of the luminal diameter in one or more coronary arteries) and 57 with severe atheromatosis (70% stenosis). Plasma sPLA2 activity was significantly higher in subjects with severe [127.7 U/ml (102.3-162.7); p0.0001] and mild/moderate [112.0 U/ml (100.6-146.9); p0.0001] atheromatosis than in controls [19.8 U/ml (15.1-32.1)]. In a multiple logistic regression model, adjusted for age, gender, body mass index, tabagism, hypertension, sedentarism, family history for coronary artery disease, diabetes mellitus, total cholesterol, HDLc, LDLc, triglycerides, high sensitivity C-reactive protein and phospholipase A2, only sPLA2 was observed to be independently associated with severe CAD (70% of stenosis) (p0.0001). |
| Databáze: | OpenAIRE |
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