Are depressive symptoms in mild cognitive impairment predictive of conversion to dementia?
| Autor: | Peter Paul De Deyn, Marc Bosmans, Ellen Elisa De Roeck, Eva Dierckx, Sebastiaan Engelborghs, Ingrid Ponjaert-Kristoffersen |
|---|---|
| Přispěvatelé: | Molecular Neuroscience and Ageing Research (MOLAR), Faculty of Psychology and Educational Sciences, Clinical sciences, Neurology, Psychopathology and Information Processing in Older Adults, Clinical and Lifespan Psychology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Longitudinal study PROGRESSION GERIATRIC DEPRESSION Neuropsychological Tests 0302 clinical medicine depressive symptoms Surveys and Questionnaires Psychology Longitudinal Studies Depression (differential diagnoses) Medicine(all) RISK Cognition Alzheimer's disease Cognitive test ALZHEIMERS-DISEASE Psychiatry and Mental health Clinical Psychology Dementia/diagnosis Predictive value of tests Memory Disorders/diagnosis depression Disease Progression Regression Analysis Geriatric Depression Scale Female Clinical psychology Geriatric Assessment/statistics & numerical data Cognitive Dysfunction/diagnosis DIAGNOSIS behavioral disciplines and activities 03 medical and health sciences mild cognitive impairment Depression/diagnosis Predictive Value of Tests mental disorders medicine Memory impairment Dementia Humans Cognitive Dysfunction COHORT conversion Geriatric Assessment METAANALYSIS Aged Memory Disorders 030214 geriatrics CUED-RECALL medicine.disease Human medicine Geriatrics and Gerontology aged 80 and over FOLLOW-UP Gerontology 030217 neurology & neurosurgery Follow-Up Studies dementia |
| Zdroj: | International Psychogeriatrics, 28(6), 921-928. Cambridge University Press International psychogeriatrics |
| ISSN: | 1041-6102 |
| Popis: | Background:Depressive symptoms are common in amnestic mild cognitive impairment (aMCI). The association between depressive symptoms and conversion to dementia is not yet clear. This longitudinal study was conducted to ascertain whether depressive symptoms in aMCI patients are predictive of conversion to dementia.Methods:35 aMCI patients participated in this study. All participants underwent cognitive testing and were administered the geriatric depression scale (GDS) to determine the presence of depressive symptoms. A score equaling or higher than 11 on the GDS was taken as the cut-off point for presence of significant depressive symptoms. Conversion to dementia was assessed at follow-up visits after 1.5, 4, and 10 years.Results:31.4% of the patients reported depressive symptoms at baseline. None of the cognitive measures revealed a significant difference at baseline between patients with and without depressive symptoms. After 1.5, 4, and 10 years respectively 6, 14, and 23 patients had converted to dementia. Although the GDS scores at baseline did not predict conversion to dementia, the cognitive measures and more specifically a verbal cued recall task (the memory impairment scale-plus) was a good predictor for conversion.Conclusions:Based on this dataset, the presence of depressive symptoms in aMCI patients is not predictive of conversion to dementia. |
| Databáze: | OpenAIRE |
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