Studies on the plasma membrane of normal and psoriatic keratinocytes. 5. Lectin binding
| Autor: | José J.M.A. Hurk, P.E.J. Erp, H. Roelfzema, J.M. Gommans, Mieke Bergers, Paul D. Mier |
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| Rok vydání: | 1982 |
| Předmět: |
Binding Sites
biology Epidermis (botany) Cell Membrane Mannose Dermatology medicine.disease Molecular biology Wheat germ agglutinin Sialic acid Glycocalyx chemistry.chemical_compound Agglutinin Biochemistry chemistry Concanavalin A Psoriasis Lectins biology.protein medicine Carbohydrate Metabolism Humans Keratins Skin |
| Zdroj: | The British journal of dermatology. 106(3) |
| ISSN: | 0007-0963 |
| Popis: | SUMMARY The glycocalyx of epidermal keratinocytes from psoriatic patients has been investigated by means of lectins. Striking changes were found in the levels of glucose and/or mannose (concanavalin A) and of N-acetylglucosamine and/or sialic acid (wheat germ agglutinin) on the surface of cells from the psoriatic lesion. Smaller but significant changes were seen in the clinically uninvolved epidermis of the patient. A marked increase in the affinity of the cell surface for Ulex europus agglutinin (fucose-specific) confirms our previous reports of structural alterations in fucose-containing oligosaccharides in psoriasis. |
| Databáze: | OpenAIRE |
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