Antioxidant effect of diethyldithiocarbamate on microsomal lipid peroxidation assessed by low-level chemiluminescence and alkane production
| Autor: | Armin Müller, Bartoli Gm, Enrique Cadenas, Helmut Sies |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Lipid Peroxides
Luminescence Antioxidant Chemiluminescence Dithioerythritol Iron Induction period medicine.medical_treatment Lipid peroxidation Biophysics Ascorbic Acid Biochemistry law.invention chemistry.chemical_compound Thiocarbamates Structural Biology law Free radical Alkanes Genetics medicine Animals Molecular Biology Penicillamine Cell Biology Glutathione Rats Adenosine Diphosphate chemistry Alkane formation Diethydithiocarbamate Microsomes Liver Microsome Ditiocarb medicine.drug |
| Zdroj: | FEBS Letters. (2):371-374 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(83)80319-6 |
| Popis: | Different thiol-containing compounds, such as diethyldithiocarbamate (DDC), glutathione, penicillamine, and dithioerythritol have been chosen to study their effect on ascorbate/Fe-ADP-induced lipid peroxidation, detected by low-level chemiluminescence and alkane production. In the concentration range used, these thiols exerted a temporary protection against lipid peroxidation by lengthening the induction period; after overcoming this induction period, no substantial inhibition of either chemiluminescence or alkane production was observed. DDC was effective in protecting against lipid peroxidation in the nanomolar range, whereas the group of other thiol-containing molecules operated in the millimolar range. |
| Databáze: | OpenAIRE |
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