Genetic analysis of the (CTG)n NOTCH4 polymorphism in 65 multiplex bipolar pedigrees
| Autor: | Theresa Swift-Scanlan, Tsuo Hung Lan, M. D. Fallin, Jennifer M. Coughlin, James B. Potash, J. R. DePaulo, Melvin G. McInnis |
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| Rok vydání: | 2002 |
| Předmět: |
Bipolar Disorder
Genotype Receptors Cell Surface Locus (genetics) Pedigree chart Biology Genetic analysis Major Histocompatibility Complex Exon Trinucleotide Repeats Genetic linkage Proto-Oncogene Proteins mental disorders Genetics medicine Humans Bipolar disorder Receptor Notch4 Biological Psychiatry Genetics (clinical) Genetic association Polymorphism Genetic Base Sequence Receptors Notch medicine.disease Psychiatry and Mental health Peptides Trinucleotide repeat expansion |
| Zdroj: | Psychiatric Genetics. 12:43-47 |
| ISSN: | 0955-8829 |
| DOI: | 10.1097/00041444-200203000-00006 |
| Popis: | A strong genetic association between the NOTCH4 locus on chromosome 6 and schizophrenia was recently reported. Based on the data suggesting overlapping susceptibility for schizophrenia and bipolar disorder, we genotyped the polymorphic (CTG)n encoding polyleucine repeat in exon 1 of NOTCH4 in 65 pedigrees ascertained for a genetic linkage study of bipolar disorder. In addition, we analyzed a subset of our pedigrees with psychotic features at this locus. We failed to find any association between the (CTG)n NOTCH4 polymorphism and either the bipolar or the psychotic bipolar phenotype in our 65 pedigrees. |
| Databáze: | OpenAIRE |
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