MRI atlas of the human hypothalamus
| Autor: | Didier Dewailly, Serge Blond, Eglantine Balland, Vincent Prevot, Pierre Besson, Patrice Jissendi, Jean Paul Francke, J.-P. Pruvo, Marc Baroncini |
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| Přispěvatelé: | Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Service de neurochirurgie, Hôpital Roger Salengro [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de neuroradiologie [Lille], Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire d'anatomie, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'endocrinologie, gynécologie et médecine de la reproduction, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Prevot, Vincent |
| Rok vydání: | 2012 |
| Předmět: |
Male
human hypothalamus anatomy Cognitive Neuroscience Hypothalamus MESH: Atlases as Topic Anterior commissure Biology Brain mapping MESH: Magnetic Resonance Imaging coronal plane White matter Young Adult 03 medical and health sciences Atlases as Topic 0302 clinical medicine medicine Humans [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Anatomy Artistic MESH: Brain Mapping 030304 developmental biology 2. Zero hunger Brain Mapping 0303 health sciences MESH: Humans medicine.diagnostic_test Fornix Magnetic resonance imaging Anatomy Magnetic Resonance Imaging MESH: Hypothalamus MESH: Anatomy Artistic MESH: Male 3. Good health medicine.anatomical_structure Ventromedial nucleus of the hypothalamus Neurology MESH: Young Adult Coronal plane Female [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH: Female Neuroscience Nucleus 030217 neurology & neurosurgery MRI |
| Zdroj: | NeuroImage NeuroImage, Elsevier, 2012, 59 (1), pp.168-80. ⟨10.1016/j.neuroimage.2011.07.013⟩ NeuroImage, 2012, 59 (1), pp.168-80. ⟨10.1016/j.neuroimage.2011.07.013⟩ |
| ISSN: | 1053-8119 1095-9572 |
| DOI: | 10.1016/j.neuroimage.2011.07.013 |
| Popis: | International audience; Gaining new insights into the anatomy of the human hypothalamus is crucial for the development of new treatment strategies involving functional stereotactic neurosurgery. Here, using anatomical comparisons between histology and magnetic resonance images of the human hypothalamus in the coronal plane, we show that discrete gray and white hypothalamic structures are consistently identifiable by MRI. Macroscopic and microscopic images were used to precisely annotate the MRI sequences realized in the coronal plane in twenty healthy volunteers. MRI was performed on a 1.5 T scanner, using a protocol including T1-weighted 3D fast field echo, T1-weighted inversion-recovery, turbo spin echo and T2-weighted 2D fast field echo imaging. For each gray matter structure as well as for white matter bundles, the different MRI sequences were analyzed in comparison to each other. The anterior commissure and the fornix were often identifiable, while the mammillothalamic tract was more difficult to spot. Qualitative analyses showed that MRI could also highlight finer structures such as the paraventricular nucleus, the ventromedial nucleus of the hypothalamus and the infundibular (arcuate) nucleus, brain nuclei that play key roles in the regulation of food intake and energy homeostasis. The posterior hypothalamic area, a target for deep brain stimulation in the treatment of cluster headaches, was readily identified, as was the lateral hypothalamic area, which similar to the aforementioned hypothalamic nuclei, could be a putative target for deep brain stimulation in the treatment of obesity. Finally, each of the identified structures was mapped to Montreal Neurological Institute (MNI) space. |
| Databáze: | OpenAIRE |
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