Nosocomial infections by Klebsiella pneumoniae carbapenemase producing enterobacteria in a teaching hospital

Autor: Bettina Meneghetti, Rosmari Hörner, Adenilde Salla, Roselene Alves Righi, Gabriela Seibert, Nara Lucia Frasson Dal Forno
Rok vydání: 2014
Předmět:
Male
Imipenem
Klebsiella pneumoniae
lcsh:Medicine
Drug resistance
Polymerase Chain Reaction
Carbapenems/isolation & purification
chemistry.chemical_compound
polycyclic compounds
Child
Resistência a medicamentos
Cross Infection
biology
Artigo Original
Enterobacteriaceae Infections
General Medicine
Antimicrobial
Amikacin
Female
Original Article
Gentamicin
Ertapenem
Klebsiella pneumoniae/epidemiology
medicine.drug
Adult
Carbapenêmicos/isolamento & purificação
Adolescent
Microbial Sensitivity Tests
Cross infection/prevention & control
Klebsiella pneumoniae/epidemiologia
Meropenem
beta-Lactamases
Microbiology
Young Adult
Bacterial Proteins
Enterobacteriaceae
Drug Resistance
Bacterial
medicine
Humans
Hospitals
Teaching
Retrospective Studies
business.industry
lcsh:R
Infecção hospitalar/prevenção & controle
biochemical phenomena
metabolism
and nutrition
biology.organism_classification
Klebsiella Infections
Carbapenems
chemistry
business
Zdroj: Einstein
Einstein (São Paulo), Vol 12, Iss 3, Pp 282-286
einstein (São Paulo) v.12 n.3 2014
Einstein (São Paulo)
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron:IIEPAE
ISSN: 1679-4508
Popis: Objective To analyze the profile of patients with microorganisms resistant to carbapenems, and the prevalence of the enzyme Klebsiella pneumoniae carbapenemase in interobacteriaceae. Methods Retrospective descriptive study. From the isolation in bacteriological tests ordered by clinicians, we described the clinical and epidemiological characteristics of patients with enterobacteria resistants to carbapenems at a university hospital, between March and October 2013. Results We included 47 isolated patients in this study, all exhibiting resistance to carbapenems, including 9 patients who were confirmed as infected/colonized with K. pneumoniae carbapenemase. Isolation in tracheal aspirates (12; 25.5%) predominated. The resistance to ertapenem, meropenem, and imipenem was 91.5%, 83.0% and 80.0%, respectively. Aminoglycosides was the class of antimicrobials that showed the highest sensitivity, 91.5% being sensitive to amikacin and 57.4% to gentamicin. Conclusion The K. pneumoniae carbapenemase was an important agent in graun isotaling in hospital intection. The limited therapeutic options emphasize the need for rapid laboratory detection, as well as the implementation of measures to prevent and control the spread of these pathogens.
Databáze: OpenAIRE
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