Prevention of Renal Damage by Angiotensin II Blockade, Accompanied by Increased Renal Hepatocyte Growth Factor in Experimental Hypertensive Rats
| Autor: | Atsushi Moriguchi, Tadahiko Nishii, Yoshikage Yo, Jitsuo Higaki, Ryuichi Morishita, Naruya Tomita, Keiko Matsumoto, Toshikazu Nakamura, Toshio Ogihara, Kunio Matsumoto |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Hypertension Renal Time Factors Pyridines Angiotensin-Converting Enzyme Inhibitors Blood Pressure Cilazapril Kidney Rats Inbred WKY Angiotensin Receptor Antagonists Rats Inbred SHR Internal medicine Renin–angiotensin system Internal Medicine medicine Animals RNA Messenger Antihypertensive Agents Hepatocyte Growth Factor business.industry Angiotensin II Imidazoles Kidney metabolism Hydralazine Blotting Northern Rats Kidney Tubules medicine.anatomical_structure Endocrinology Renal pathology Data Interpretation Statistical Hepatocyte growth factor business medicine.drug |
| Zdroj: | Hypertension. 34:279-284 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.34.2.279 |
| Popis: | Abstract —Hepatocyte growth factor (HGF) is a unique growth factor that has many protective functions against renal damage. Our previous study demonstrated that HGF stimulated the growth of endothelial and epithelial cells without the replication of mesangial cells. Moreover, angiotensin (Ang) II significantly decreased local HGF production in mesangial cells. Therefore, we examined the effects of Ang II blockade on renal HGF expression and renal damage in experimental hypertensive rats. An angiotensin-converting enzyme inhibitor (cilazapril; 10 mg · kg −1 · d −1 ), an Ang II type 1 receptor antagonist (E-4177; 30 mg · kg −1 · d −1 ), hydralazine (8 mg · kg −1 · d −1 ), and vehicle were administered to 16-week-old stroke-prone spontaneously hypertensive rats (SHR-SP) for 3 weeks. Renal damage was evaluated with a computer analysis system, and renal HGF mRNA was measured by Northern blot analysis. Blood pressure of SHR-SP was significantly decreased by all drug treatments compared with vehicle. Moreover, cilazapril, E-4177, and hydralazine significantly decreased the thickening and necrosis of blood vessels compared with vehicle. Similarly, degeneration and necrosis of glomeruli were also markedly improved by cilazapril and E-4177 ( P P |
| Databáze: | OpenAIRE |
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