Tryptophan restriction causes long-term plastic changes in corticofrontal pyramidal neurons
| Autor: | Ignacio González-Burgos, A.R. Del Angel-Meza, Alfredo Feria-Velasco, G Barajas-López |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Serotonin
Dendritic spine Prefrontal Cortex Serotonergic Rats Sprague-Dawley symbols.namesake Developmental Neuroscience medicine Animals Receptor Neuronal Plasticity Chemistry Pyramidal Cells Body Weight Tryptophan Dendrites Organ Size Golgi apparatus Cortex (botany) Diet Rats medicine.anatomical_structure nervous system Cerebral cortex symbols Female Neuroscience Acetylcholine Developmental Biology medicine.drug |
| Zdroj: | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 14(5) |
| ISSN: | 0736-5748 |
| Popis: | A Golgi study of third-layer pyramidal neurons from the corticofrontal cortex of tryptophanrestricted rats was carried out. At 40 days of age, dendritic arborization from treated rats was less profuse than that seen in control rats, and enlargement of dendritic processes, as well as an increase of the number of dendritic spines, were observed in 60-day-old rats. These plastic responses could be mediated either by a decrease in serotonin, which acts on the serotoninergic receptors of pyramidal neurons, or through an indirect mechanism mediated by cortical interneurons, or by serotoninergic modulation of the activity of other cortical neurotransmitters such as acetylcholine. Also, it could represent compensatory mechanisms underlying behavioral performance in some paradigms related to several cognitive processes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text