Ultrasound assisted synthesis of 6-flavonyl substituted 1,4-dihydro-benzo[d][1,3]oxazin-2-ones via Suzuki–Miyaura coupling under Pd/C catalysis
| Autor: | Manojit Pal, Mandava Venkata Basaveswara Rao, Namburi Suresh, Gutta Lakshmi Prasanna |
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| Rok vydání: | 2019 |
| Předmět: |
Reaction mechanism
Chemistry(all) 010405 organic chemistry Chemistry General Chemical Engineering General Chemistry 010402 general chemistry Ultrasound assisted 01 natural sciences Medicinal chemistry 0104 chemical sciences D-1 Catalysis lcsh:Chemistry Coupling (electronics) lcsh:QD1-999 Yield (chemistry) Chemical Engineering(all) Organic chemistry Ultrasound irradiation |
| Zdroj: | Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 4220-4230 (2019) |
| ISSN: | 1878-5352 |
| DOI: | 10.1016/j.arabjc.2016.05.009 |
| Popis: | Pd/C facilitated Suzuki–Miyaura coupling of 2-aryl-3-bromoflavones with 4,4-disubstituted (1,4-dihydro-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acids under ultrasound irradiation. The methodology involving the use of 10%Pd/C-TBAB-K2CO3 system in DMF/H2O afforded corresponding 6-flavonyl substituted 1,4-dihydro-benzo[d][1,3]oxazin-2-ones in good yield within a short reaction time. The role of ultrasound and catalyst along with the recyclability of Pd/C was examined and a reaction mechanism is proposed. Keywords: Pd/C, Ultrasound, Suzuki–Miyaura coupling, Flavones, Benzoxazin-2-one |
| Databáze: | OpenAIRE |
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