Early-life stress induces EAAC1 expression reduction and attention-deficit and depressive behaviors in adolescent rats
| Autor: | Seoul Lee, Hye Sun Kim, Han Byeol Kim, Ran Sook Woo, Ji-Young Yoo, Ji Hye Park, San Won Suh, Seung Yeon Yoo, Jun Ho Lee, Tai Kyoung Baik |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Immunology Hippocampus Molecular neuroscience Hippocampal formation lcsh:RC254-282 Article 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine Medicine lcsh:QH573-671 lcsh:Cytology business.industry Depression Glutamate receptor Cell Biology lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Phenotype Pathophysiology 030104 developmental biology medicine.anatomical_structure Endocrinology Cerebral cortex GABAergic business 030217 neurology & neurosurgery |
| Zdroj: | Cell Death Discovery Cell Death Discovery, Vol 6, Iss 1, Pp 1-13 (2020) |
| ISSN: | 2058-7716 |
| Popis: | Neonatal maternal separation (NMS), as an early-life stress (ELS), is a risk factor to develop emotional disorders. However, the exact mechanisms remain to be defined. In the present study, we investigated the mechanisms involved in developing emotional disorders caused by NMS. First, we confirmed that NMS provoked impulsive behavior, orienting and nonselective attention-deficit, abnormal grooming, and depressive-like behaviors in adolescence. Excitatory amino acid carrier 1 (EAAC1) is an excitatory amino acid transporter expressed specifically by neurons and is the route for the neuronal uptake of glutamate/aspartate/cysteine. Compared with that in the normal control group, EAAC1 expression was remarkably reduced in the ventral hippocampus and cerebral cortex in the NMS group. Additionally, EAAC1 expression was reduced in parvalbumin-positive hippocampal GABAergic neurons in the NMS group. We also found that EAAC1-knockout (EAAC1−/−) mice exhibited impulsive-like, nonselective attention-deficit, and depressive-like behaviors compared with WT mice in adolescence, characteristics similar to those of the NMS behavior phenotype. Taken together, our results revealed that ELS induced a reduction in EAAC1 expression, suggesting that reduced EAAC1 expression is involved in the pathophysiology of attention-deficit and depressive behaviors in adolescence caused by NMS. |
| Databáze: | OpenAIRE |
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