Prognostic value of pro-adrenomedullin and copeptin in acute infective endocarditis

Autor: Maria Paola Ursi, Roberto Andini, Emanuele Durante-Mangoni, Luigi Atripaldi, Rosa Zampino, Domenico Iossa, Rosa Molaro, Silvia Leonardi, Oriana Fabrazzo, Lorenzo Bertolino
Přispěvatelé: Zampino, R., Iossa, D., Ursi, M. P., Bertolino, L., Andini, R., Molaro, R., Fabrazzo, O., Leonardi, S., Atripaldi, L., Durante-Mangoni, E.
Rok vydání: 2020
Předmět:
Male
Protein Precursor
Organ dysfunction
Disease
030204 cardiovascular system & hematology
Procalcitonin
Adrenomedullin
0302 clinical medicine
Retrospective Studie
Endocarditi
Hospital Mortality
Aged
80 and over
Endocarditis
Glycopeptides
Heart valve disease
Middle Aged
Staphylococcal Infections
Prognosis
Infectious Diseases
C-Reactive Protein
Infective endocarditis
Biomarker (medicine)
Female
medicine.symptom
Human
Research Article
Adult
medicine.medical_specialty
Adolescent
Prognosi
Heart failure
Glycopeptide
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Young Adult
Copeptin
Internal medicine
Streptococcal Infections
Streptococcal Infection
medicine
Humans
lcsh:RC109-216
Protein Precursors
Mortality
Staphylococcal Infection
Aged
Retrospective Studies
business.industry
030208 emergency & critical care medicine
Retrospective cohort study
Biomarker
Endocarditis
Bacterial
medicine.disease
business
Biomarkers
Kidney disease
Zdroj: BMC Infectious Diseases
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-11 (2021)
ISSN: 1471-2334
Popis: Background Infective endocarditis (IE) is a life-threatening disease whose prognosis is often difficult to predict based on clinical data. Biomarkers have been shown to favorably affect disease management in a number of cardiac disorders. Aims of this retrospective study were to assess the prognostic role of procalcitonin (PCT), pro-adrenomedullin (pro-ADM) and copeptin in IE and their relation with disease characteristics and the traditional biomarker C-reactive protein (CRP). Methods We studied 196 patients with definite IE. Clinical, laboratory and echocardiography parameters were analyzed, with a focus on co-morbidities. PCT, pro-ADM and copeptin were measured on stored plasma samples obtained on admission during the acute phase of the disease. Results Pro-ADM and copeptin were significantly higher in older patients and associated with prior chronic kidney disease. Pro-ADM was an independent predictor of hospital mortality (OR 3.29 [95%C.I. 1.04–11.5]; p = 0.042) whilst copeptin independently predicted 1-year mortality (OR 2.55 [95%C.I. 1.18–5.54]; p = 0.017). A high PCT value was strictly tied with S. aureus etiology (p = 0.001). CRP was the only biomarker associated with embolic events (p = 0.003). Conclusions Different biomarkers correlate with distinct IE outcomes. Pro-ADM and copeptin may signal a worse prognosis of IE on admission to the hospital and could be used to identify patients who need more aggressive treatment. CRP remains a low-cost marker of embolic risk. A high PCT value should suggest S. aureus etiology.
Databáze: OpenAIRE
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