Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201
| Autor: | Sung-Hee Nam, Sang-Han Lee, Kwang-Gil Lee, Dong-Yoon Nam, Jong-Guk Kim, Joo-Hong Yeo, Jin-Chul Heo, Cheol-Sik Yoon, Chul-Hong Park |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Ovalbumin Cell Spleen Biology Microbiology Cell Line Mice Immune system Genetics medicine Animals Anti-Asthmatic Agents Lung Sensitization Medicine East Asian Traditional Mice Inbred BALB C Mycelium General Medicine medicine.disease Asthma Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Apoptosis Concanavalin A Cordyceps biology.protein Cytokines Bronchial Hyperreactivity Infiltration (medical) |
| Zdroj: | International journal of molecular medicine. 26(3) |
| ISSN: | 1791-244X |
| Popis: | This study investigated the effects of mycelial extract and culture filtrate of Cordyceps sphecocephala J201 on airway hyper-responsiveness, pulmonary immune cell infiltration, and Th2 cytokine expression in animal models of asthma. After Concanavalin A (Con A) activation of mouse primary spleen cells, the IL-4 and IL-13 cytokine expression were significantly decreased in the presence of the mycelial extract and culture filtrate of Cordyceps sphecocephala J201. The asthma model was induced by sensitization to ovalbumin by intraperitoneal (i.p.) injection treatment in mice. The Cordyceps sphecocephala J201 mycelial extract was injected in order to assess the effects of anti-asthmatic activity by comparing lung cell infiltration in ovalbumin-induced asthmatic mice. The results revealed that the increased IL-4, IL-13 and IL-25 expression were controlled by the mycelial extract and culture filtrate of Cordyceps sphecocephala J201, indicating that the extracts reduced the undesirable immune responses and/or cytokine expression exhibited in asthma. |
| Databáze: | OpenAIRE |
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