Lifestyle factors and oncogenic papillomavirus infection in a high-risk male population
| Autor: | Angel de la Orden, Sonia Pérez, Máximo Castro, Manuel Carballo, Moises Rodríguez, Elena Lopez-Diez, Jorge Sanchez, Antonio Ojea, Sheila Almuster, Ruben Montero, Amparo Iñarrea, Miguel Perez |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Viral Diseases
Physiology lcsh:Medicine Pathology and Laboratory Medicine Cervical Cancer Genital warts 0302 clinical medicine Circumcision Reproductive Physiology Epidemiology Copulation Medicine and Health Sciences 030212 general & internal medicine Papillomaviridae Reproductive System Procedures lcsh:Science Cervical cancer Univariate analysis education.field_of_study Multidisciplinary biology Transmission (medicine) virus diseases Infectious Diseases Oncology Medical Microbiology 030220 oncology & carcinogenesis Viral Pathogens Viruses Pathogens Research Article medicine.medical_specialty Human Papillomavirus Infection Papillomaviruses Urology Population Sexually Transmitted Diseases Surgical and Invasive Medical Procedures Microbiology HPV-16 03 medical and health sciences Internal medicine medicine Sex organ education Condyloma Acuminata Microbial Pathogens Biology and life sciences business.industry Genitourinary Infections lcsh:R Organisms Human Papillomavirus Cancers and Neoplasms medicine.disease biology.organism_classification Surgery lcsh:Q business DNA viruses Gynecological Tumors |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 9, p e0184492 (2017) |
| ISSN: | 1932-6203 |
| Popis: | Background High risk human papillomavirus (HR-HPV) infection in males is a health issue with implications for HPV-related lesions in their partners. The identification of risk factors for male infection may improve our understanding of HR-HPV transmission and prevention. The aim of this study was to evaluate the relationships between lifestyle, genital warts and HR-HPV infection. The study was focused on men with an increased risk of HR-HPV infection: male sexual partners of women diagnosed with high-grade squamous intraepithelial cervical lesions. Methods Men were enrolled and prospectively recruited within the first six months after diagnosis of cervical lesions in their female partners (n = 175, 2013–2016). Epidemiological and sexual behaviour data were obtained. The presence of genital warts was established by visual inspection. Detection and genotyping of HR-HPV infection in genital samples were performed with a Linear Array HPV Genotyping Test. All HR-HPV positive men were offered a follow-up exam at 12 months. SPSS version 19 was used for statistical analysis. Results and discussion The prevalence of HR-HPV infection in men was 45.1% (79/175). Genital warts were observed in 10.3% (18/175) of the subjects. Detection of genital warts (OR 3.5, p = 0.015), smoking habits (OR 2.3, p = 0.006) and sexual debut before 16 years old (OR 2, p = 0.035) were associated with an increased risk for HR-HPV infection (univariate analysis). This association was also observed for genital warts and smoking status in a multivariate analysis. The same genotype was found after one year in 71.4% (20/28) of subjects. Conclusions The presence of genital warts and smoking habits seem to be associated with a higher risk of HR-HPV infection in males. Earlier sexual debut may increase this risk. Extensive knowledge of the natural history of HR-HPV infection in males is an absolute requirement for the design and implementation of prevention strategies for the general population as well as for specific populations such as couples after treatment for high-grade cervical lesions. |
| Databáze: | OpenAIRE |
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