HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population
| Autor: | K. Douroudis, K. Tarassi, A. Kominakis, Ch. Papasteriades, T. E. Athanassiades, F. Giannakopoulos, N. Thalassinos |
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| Rok vydání: | 2007 |
| Předmět: |
Immunology
Population Osteoporosis Human leukocyte antigen Biology Major histocompatibility complex Biochemistry HLA-B7 Antigen Antigen Gene Frequency Bone Density HLA Antigens Risk Factors HLA-DQ Antigens Genetics medicine Immunology and Allergy Humans Allele education Alleles Osteoporosis Postmenopausal HLA-DR Serological Subtypes Bone mineral education.field_of_study Greece General Medicine HLA-DR Antigens Middle Aged medicine.disease Genetic marker Case-Control Studies biology.protein Female |
| Zdroj: | Tissue antigens. 69(6) |
| ISSN: | 0001-2815 |
| Popis: | It is well established that genetic factors play an important role in the pathogenesis of osteoporosis, a common condition characterized by reduced bone mass and increased fracture risk. The major histocompatibility complex in humans, known as human leukocyte antigen (HLA) region, is the most polymorphic human genetic system and it is known as a cluster of genetic markers, associated with several diseases. In order to evaluate the contribution of HLA alleles in bone mass loss, polymorphisms in the HLA class I (-A, -B and -Cw) and class II (-DR and -DQ) antigens were studied in 126 postmenopausal women of Greek origin. It was found that HLA-B7 (P= 0.069), -DR15 (P= 0.019) and -DQ6 (P= 0.026) were associated with a lower bone mineral density measured at the forearm. This study shows a significant association between HLA alleles and bone mass loss in the population studied. |
| Databáze: | OpenAIRE |
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