Insights into Matriptase-2 Substrate Binding and Inhibition Mechanisms by Analyzing Active-Site-Mutated Variants
| Autor: | Marit Stirnberg, Michael Gütschow, Jürgen Bajorath, Mihiret T. Sisay, Eva Maurer, Torsten Steinmetzer |
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| Rok vydání: | 2011 |
| Předmět: |
Models
Molecular Molecular model Matriptase 2 Biochemistry Substrate Specificity Catalytic Domain Drug Discovery Humans Protease Inhibitors Amino Acid Sequence General Pharmacology Toxicology and Pharmaceutics Pharmacology biology Chemistry Kazal-type serine protease inhibitor domain Serine Endopeptidases Organic Chemistry Mutagenesis Membrane Proteins Active site Substrate (chemistry) HEK293 Cells Mutation Mutagenesis Site-Directed biology.protein Molecular Medicine Peptides |
| Zdroj: | ChemMedChem. 7:68-72 |
| ISSN: | 1860-7179 |
| DOI: | 10.1002/cmdc.201100350 |
| Databáze: | OpenAIRE |
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