Nanosized Delivery Systems for Therapeutic Proteins: Clinically Validated Technologies and Advanced Development Strategies
| Autor: | Maria Isabel Martinez Espinoza, Filippo Moncalvo, Francesco Cellesi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
liposomes Biocompatible polymers protein delivery Histology lcsh:Biotechnology Biomedical Engineering Bioengineering Nanotechnology Review 02 engineering and technology 03 medical and health sciences lcsh:TP248.13-248.65 Medicine polymer conjugates Protein therapeutics therapeutic proteins nanocarriers business.industry Polymeric nanocarriers PEGylation Bioengineering and Biotechnology 021001 nanoscience & nanotechnology 030104 developmental biology Nanocarriers 0210 nano-technology business Biotechnology |
| Zdroj: | Frontiers in Bioengineering and Biotechnology, Vol 8 (2020) Frontiers in Bioengineering and Biotechnology |
| ISSN: | 2296-4185 |
| DOI: | 10.3389/fbioe.2020.00089/full |
| Popis: | The impact of protein therapeutics in healthcare is steadily increasing, due to advancements in the field of biotechnology and a deeper understanding of several pathologies. However, their safety and efficacy are often limited by instability, short half-life and immunogenicity. Nanodelivery systems are currently being investigated for overcoming these limitations and include covalent attachment of biocompatible polymers (PEG and other synthetic or naturally derived macromolecules) as well as protein nanoencapsulation in colloidal systems (liposomes and other lipid or polymeric nanocarriers). Such strategies have the potential to develop next-generation protein therapeutics. Herein, we review recent research progresses on these nanodelivery approaches, as well as future directions and challenges. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|