Central Dopamine D2 Receptors Regulate Growth-HormoneDependent Body Growth and Pheromone Signaling to Conspecific Males
| Autor: | M. Inés Pérez-Millán, Diego M. Gelman, Isabel Garcia Tornadu, Daniela Noain, Marcela Peper, Estefanía P. Bello, Marcelo Rubinstein, Damasia Becu-Villalobos, Rodrigo Casas Cordero, Malcolm J. Low, Guillermina Maria Luque |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Pituitary gland Medicina Clínica Pheromones Oligodeoxyribonucleotides Antisense Nestin PITUITARY GLAND Eating Mice Intermediate Filament Proteins Endocrinología y Metabolismo purl.org/becyt/ford/3.2 [https] Body Size Insulin-Like Growth Factor I Receptor Major urinary proteins General Neuroscience Catatonia Articles purl.org/becyt/ford/3.1 [https] Medicina Básica medicine.anatomical_structure Sex pheromone Pituitary Gland Benzamides Female purl.org/becyt/ford/3 [https] medicine.symptom medicine.drug Protein Binding medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD Somatotropic cell Neurociencias Radioimmunoassay Mice Transgenic Nerve Tissue Proteins Biology Tritium Dopamine Internal medicine Dopamine receptor D2 medicine Animals MICE INBRED BALB C57BL Analysis of Variance Aggression Receptors Dopamine D2 Body Weight Proteins Prolactin DOPAMINE D2 RECEPTOR Mice Inbred C57BL Endocrinology Social Dominance Case-Control Studies Growth Hormone Dopamine Antagonists Haloperidol GROWTH HORMONE Territoriality |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| Popis: | Competition between adult males for limited resources such as food and receptive females is shaped by the male pattern of pituitary growth hormone (GH) secretion that determines body size and the production of urinary pheromones involved in male-to-male aggression. In the brain, dopamine (DA) provides incentive salience to stimuli that predict the availability of food and sexual partners. Although the importance of the GH axis and central DA neurotransmission in social dominance and fitness is clearly appreciated, the two systems have always been studied unconnectedly. Here we conducted a cell-specific genetic dissection study in conditional mutant mice that selectively lack DA D2 receptors (D2R) from pituitary lactotropes (lacDrd2KO) or neurons (neuroDrd2KO). Whereas lacDrd2KO mice developed a normal GH axis, neuroDrd2KO mice displayed fewer somatotropes; reduced hypothalamic Ghrh expression, pituitary GH content, and serum IGF-I levels; and exhibited reduced body size and weight. As a consequence of a GH axis deficit, neuroDrd2KO adult males excreted low levels of major urinary proteins and their urine failed to promote aggression and territorial behavior in control male challengers, in contrast to the urine taken from control adult males. These findings reveal that central D2Rs mediate a euroendocrineexocrine cascade that controls the maturation of the GH axis and downstream signals that are critical for fitness, social dominance, and competition between adult males. Fil: Noain, Daniela Maria Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones En Ingeniería Genética y Biología Molecular; Argentina Fil: Pérez Millán, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Bello Gay, Estefania Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones En Ingeniería Genética y Biología Molecular; Argentina Fil: Luque, Guillermina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Casas Cordero, Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones En Ingeniería Genética y Biología Molecular; Argentina Fil: Gelman, Diego Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones En Ingeniería Genética y Biología Molecular; Argentina Fil: Peper, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones En Ingeniería Genética y Biología Molecular; Argentina Fil: Isabel Garcia-tornadu. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Malcolm J Low. Michigan State University; Estados Unidos; Fil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones En Ingeniería Genética y Biología Molecular; Argentina |
| Databáze: | OpenAIRE |
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