Enantioseparation of racemic N-acylarylalkylamines on various amino alcohol derived tau-acidic chiral stationary phases
| Autor: | Sung Hyun Im, Ji Yeon Park, Seong-Ho Choi, Tae Hyuk Kim, Kwang-Pill Lee, Jae Jeong Ryoo, Jung Hag Park, Young Han Jeong |
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| Rok vydání: | 2003 |
| Předmět: |
Chromatography
Magnetic Resonance Spectroscopy Spectrophotometry Infrared Stereochemistry Silica gel medicine.drug_class Organic Chemistry Alcohol Carboxamide Stereoisomerism General Medicine Biochemistry High-performance liquid chromatography Amino Alcohols Analytical Chemistry Chiral column chromatography chemistry.chemical_compound chemistry medicine Organic chemistry Enantiomer Amines Aliphatic compound Derivative (chemistry) Chromatography High Pressure Liquid |
| Zdroj: | Journal of chromatography. A. 987(1-2) |
| ISSN: | 0021-9673 |
| Popis: | Five π-acidic chiral stationary phases (CSPs), CSP 4, CSP 5, CSP 6, CSP 7 and CSP 8, were prepared by connecting the N-(3,5-dimethylbenzoyl) derivative of (R)-alaninol, (S)-leucinol, (1S,2R)-ephedrine and (S)-tert-leucinol and the O-(3,5-dinitrobenzoyl) derivative of (R)-phenylglycinol to silica gel through a carbamate or urea linkage. The CSPs were applied to the resolution of various racemic N-acyl-1-naphthylaminoalkanes by chiral HPLC, and the chromatographic resolution results were compared with those of previously reported CSPs (CSP 2, CSP 3), which are derived from N-(3,5-dinitrobenzoyl)-(1S,2R)-norephedrine and N-(3,5-dinitrobenzoyl-(R)-phenylglycinol. Based on a comparison of the resolution results for each CSP, the role of each functional group on the five chiral selectors is explained. |
| Databáze: | OpenAIRE |
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