Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma
| Autor: | Marie Kurokawa, Miho Watanabe Nemoto, R. Harada, Takashi Uno, G. Togasaki, Yuma Iwai, Hiroki Kobayashi |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Brachytherapy Planning target volume Uterine Cervical Neoplasms Computed tomography Cervix Uteri Magnetic Resonance Imaging Interventional Radiography Interventional Multimodal Imaging Workflow 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Cervical carcinoma medicine Image guided brachytherapy Humans Radiology Nuclear Medicine and imaging Radiation treatment planning medicine.diagnostic_test business.industry Radiotherapy Planning Computer-Assisted Radiotherapy Dosage Radiation therapy 030220 oncology & carcinogenesis Female Radiology Tomography X-Ray Computed Nuclear medicine business Combination method |
| Zdroj: | Japanese Journal of Radiology. 35:760-765 |
| ISSN: | 1867-108X 1867-1071 |
| Popis: | We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained. The MR image set was registered to the subsequent brachytherapy treatment planning CT using the applicator for rigid body registration. To demonstrate the registration quality, we used here the Dice index as a measurement of tandem delineation overlap between CT and MRI. The median Dice index was 0.879 (range 0.610–0.932), which indicated that the contours on CT and MRI fitted well. With this combination method, the median D90 of HR CTV and the calculated D2 cm3 of the bladder, rectum, and sigmoid in each fraction were 7.2 (4.0–10.4), 5.9 (2.3–7.7), 4.0 (1.9–6.7), and 3.8 (0.6–7.2) Gy, respectively. Our described method of MRI-guided IGBT offers a practical option for the benefits of target delineation. |
| Databáze: | OpenAIRE |
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