An analysis of ovarian cancer in the Million Women Study

Autor:	Manuel Neves-e-Castro
Rok vydání:	2007
Předmět:	Risk Million Women Study medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Physical exercise Endocrinology Quality of life Symptom relief Odds Ratio medicine Humans Longitudinal Studies Ovarian Neoplasms Gynecology Portugal Obstetrics business.industry Estrogen Replacement Therapy Obstetrics and Gynecology Hormone replacement therapy (menopause) medicine.disease Obesity Postmenopause Attributable risk Female Ovarian cancer business
Zdroj:	Gynecological Endocrinology. 23:410-413
ISSN:	1473-0766 0951-3590
DOI:	10.1080/09513590701483910
Popis:	In a reanalysis of the Million Women Study (MWS), their authors concluded that prolonged use of hormone replacement therapy (HRT) in postmenopausal women increases the risk of ovarian cancer. Although statistically significant their results are clinically irrelevant, since the attributable risk over 5 years is only 4 per 10 000 HRT users, a figure that is not confirmed by other large studies. This risk is much lower than those associated with obesity, lack of physical exercise, smoking and nulliparity, all of which are preventable. Therefore HRT should continue to be prescribed for symptom relief and improvement of quality of life because the benefits far outweigh the very low potential risks.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f754727d0c30880e4be6bcb25a19b9f6 https://doi.org/10.1080/09513590701483910 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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