| Autor: |
Polychronis Pavlidis, Deepak Joshi, Yasser El Sherif, Ben Warner, Shraddha Gulati, James Alexander, Gemma Cross, Tracy Dew, Hadil Abu Arqoub, John Devlin, Michael Heneghan, Patrick Dubois, Ingvar Bjarnason, Nick Powell, Bu'Hussain Hayee |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Frontline Gastroenterol |
| Popis: |
ObjectiveFaecal calprotectin (fCAL) is an established marker of intestinal inflammation in inflammatory bowel disease (IBD). Disproportionally high fCAL levels, for the severity of intestinal inflammation, have been previously observed in primary sclerosing cholangitis associated IBD (PSC-IBD). The aim of this study was to test the hypothesis that fCAL is a marker of biliary injury in PSC-IBD.MethodsWe used two cohorts: (1) post hoc analysis of a colonoscopic surveillance study allowing correlation of fCAL to endoscopic severity as measured by the ulcerative colitis endoscopic index of severity (UCEIS) in PSC-IBD (n=20) and ulcerative colitis (UC, n=20) and (2) prospective recruitment of patients attending for endoscopic retrograde cholangiopancreatography allowed the correlation of fCAL to biliary calprotectin (n=8).ResultsA strong correlation was seen between fCAL and UCEIS in UC (r=0.821, 95% CI (0.585 to 0.929), pConclusionfCAL is a surrogate marker for biliary inflammation in PSC-IBD.Trial registration numberNCT02543021. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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