Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy
| Autor: | Timothy C. Wang, Mark T. Whary, Hai Ning Shi, Cathryn Nagler-Anderson, James G. Fox, Paul L. Beck, Charles A. Dangler |
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| Rok vydání: | 2000 |
| Předmět: |
Chemokine
Inflammation General Biochemistry Genetics and Molecular Biology Helicobacter Infections Mice Immune system Antibody Specificity medicine Animals Helicobacter Strongylida Infections Nematospiroides dubius biology digestive oral and skin physiology Cancer General Medicine Immunoglobulin E Th1 Cells Helicobacter pylori biology.organism_classification medicine.disease Antibodies Bacterial digestive system diseases Mice Inbred C57BL Gastritis Immunoglobulin G Immunology biology.protein Female Chemokines medicine.symptom Antibody |
| Zdroj: | Nature Medicine. 6:536-542 |
| ISSN: | 1546-170X 1078-8956 |
| DOI: | 10.1038/75015 |
| Popis: | Helicobacter pylori is causally associated with gastritis and gastric cancer. Some developing countries with a high prevalence of infection have high gastric cancer rates, whereas in others, these rates are low. The progression of helicobacter-induced gastritis and gastric atrophy mediated by type 1 T-helper cells may be modulated by concurrent parasitic infection. Here, in mice with concurrent helminth infection, helicobacter-associated gastric atrophy was reduced considerably despite chronic inflammation and high helicobacter colonization. This correlated with a substantial reduction in mRNA for cytokines and chemokines associated with a gastric inflammatory response of type 1 T-helper cells. Thus, concurrent enteric helminth infection can attenuate gastric atrophy, a premalignant lesion. |
| Databáze: | OpenAIRE |
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