Thyroxine exacerbates absence seizures in juvenile myoclonic epilepsy
| Autor: | Saad Al Rajeh, Ahmed Chaballout, Tahir Obeid, Adnan Awada |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Pediatrics endocrine system diseases Myoclonic Jerk Epilepsies Myoclonic Progressive myoclonus epilepsy Epilepsy Internal medicine medicine Humans Euthyroid Seizure threshold business.industry Thyroid Brain Electroencephalography medicine.disease Thyroxine medicine.anatomical_structure Endocrinology Epilepsy Absence Female Neurology (clinical) Juvenile myoclonic epilepsy business Primidone medicine.drug |
| Zdroj: | Neurology. 47(2) |
| ISSN: | 0028-3878 |
| Popis: | Thyroid hormone lowers the seizure threshold in humans and has caused seizures in patients with Graves' disease. [1-3] Su et al. [4] reported high levels of thyroid hormones precipitating juvenile myoclonic epilepsy (JME) in two sisters with Graves' disease, and the seizures were not controlled until they became euthyroid. Sundaram et al. [5] reported thyroid hormone inducing petit mal status in a hypothyroid patient, although we believe that the clinical and EEG findings were not typical of petit mal status. We describe a patient with JME controlled by primidone in whom absent seizures were provoked by thyroxine administration without affecting either the myoclonic jerks or the generalized tonic-clonic seizures (GTCS). A 35-year-old Saudi school teacher was diagnosed with JME in our epilepsy clinic where she was followed for the last 10 years. JME manifested as absences at age 10 and then myoclonic jerking and GTCS at age 15. The absences were infrequent and subtle and were no longer noticeable … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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