Increased vein wall thickness in Behçet disease
| Autor: | Necdet Sut, Emine Sebnem Durmaz, Migena Gjoni, Serkan Akbas, H. Yazici, Emire Seyahi, Atilla Suleyman Dikici, Ismail Mihmanli |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Intraclass correlation Femoral vein 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans Saphenous Vein 030212 general & internal medicine Vein Retrospective Studies Observer Variation Venous Thrombosis Behcet disease Surrogate endpoint business.industry Behcet Syndrome Great saphenous vein Ultrasound Reproducibility of Results Ultrasonography Doppler Femoral Vein Middle Aged medicine.disease Venous thrombosis medicine.anatomical_structure Cardiology Female Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Vascular Surgery: Venous and Lymphatic Disorders. 7:677-684.e2 |
| ISSN: | 2213-333X |
| DOI: | 10.1016/j.jvsv.2018.11.006 |
| Popis: | Objective Lower extremity (LE) deep venous thrombosis (DVT) is the main feature of vascular involvement in Behcet disease (BD). We thought that vein wall thickness (VWT) could be a surrogate marker for venous inflammation and hence predict future vascular involvement. We assessed VWT in proximal LE veins in BD patients without DVT, BD patients with DVT, and healthy controls in a formal, masked protocol. Methods We studied 50 (43 male and 7 female) BD patients with LE DVT (group 1), 50 (43 male and 7 female) BD patients without any vascular involvement (group 2), and 50 (43 male and 7 female) age- and sex-matched apparently healthy controls (group 3). Two radiologists blinded to the diagnosis of BD used ultrasound to measure VWT of common femoral vein, femoral vein, and great saphenous vein in both legs. Interobserver reliability was assessed using the intraclass correlation coefficient and Bland-Altman plots. Results There was good agreement between the two observers. The mean VWT was significantly increased in both BD patients with LE DVT and those without apparent vascular involvement compared with the healthy controls, whereas those with LE DVT had the highest VWT. Conclusions VWT of proximal deep and superficial LE veins is increased among the BD patients without any clinical and radiologic vascular involvement. This information, after prospective work, might be useful in management and elucidating disease mechanisms in vascular BD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect