COVID-19: Coronavirus Vaccine Development Updates
| Autor: | Yuqian Yan, Zhao Jing, Junxian Ou, Wendong Lan, Jianguo Wu, Qiwei Zhang, Shan Zhao, Wei Zhao, James Chodosh, Jing Zhang, Wenyi Guan, Xiaowei Wu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine Coronavirus Disease 2019 (COVID-19) viruses Immunology Review Severe Acute Respiratory Syndrome medicine.disease_cause Middle-East Respiratory Syndrome Viral vector 03 medical and health sciences 0302 clinical medicine vaccine Pandemic medicine Animals Humans Immunology and Allergy 030212 general & internal medicine Coronavirus Vaccines Attenuated vaccine biology SARS-CoV-2 business.industry COVID-19 virus diseases Severe Acute Respiratory Syndrome Coronavirus 2 medicine.disease biology.organism_classification Antibody-Dependent Enhancement Virology 030104 developmental biology Peptide vaccine Middle East respiratory syndrome Severe acute respiratory syndrome lcsh:RC581-607 business Betacoronavirus |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 11 (2020) |
| ISSN: | 1664-3224 |
| Popis: | Coronavirus Disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a newly emerged coronavirus, and has been pandemic since March 2020 and led to many fatalities. Vaccines represent the most efficient means to control and stop the pandemic of COVID-19. However, currently there is no effective COVID-19 vaccine approved to use worldwide except for two human adenovirus vector vaccines, three inactivated vaccines, and one peptide vaccine for early or limited use in China and Russia. Safe and effective vaccines against COVID-19 are in urgent need. Researchers around the world are developing 213 COVID-19 candidate vaccines, among which 44 are in human trials. In this review, we summarize and analyze vaccine progress against SARS-CoV, Middle-East respiratory syndrome Coronavirus (MERS-CoV), and SARS-CoV-2, including inactivated vaccines, live attenuated vaccines, subunit vaccines, virus like particles, nucleic acid vaccines, and viral vector vaccines. As SARS-CoV-2, SARS-CoV, and MERS-CoV share the common genus, Betacoronavirus, this review of the major research progress will provide a reference and new insights into the COVID-19 vaccine design and development. |
| Databáze: | OpenAIRE |
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