Effects of self-administered cocaine in adolescent and adult male rats on orbitofrontal cortex-related neurocognitive functioning
| Autor: | Michael M. Mutebi, Roxann C. Harvey, Kiran Rajagopalan, Kathleen M. Kantak, Kimberly A. Dembro |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Reinforcement Schedule Adult male Central nervous system Physiology Prefrontal Cortex Self Administration Article Extinction Psychological Cocaine-Related Disorders Cognition Cocaine Dopamine Uptake Inhibitors Reward medicine Animals Learning Rats Wistar Prefrontal cortex Psychiatry Pharmacology Working memory Age Factors Rats Behavior Addictive medicine.anatomical_structure Conditioning Operant Orbitofrontal cortex Cues Self-administration Psychology Neurocognitive psychological phenomena and processes |
| Zdroj: | Psychopharmacology. 206(1) |
| ISSN: | 1432-2072 |
| Popis: | Deficits in amygdala-related stimulus-reward learning are produced following 18 drug-free days of cocaine self-administration or its passive delivery in rats exposed during adulthood. No deficits in stimulus-reward learning are produced by cocaine exposure initiated during adolescence.To determine if age of initiating cocaine exposure differentially affects behavioral functioning of an additional memory system linked to cocaine addiction, the orbitofrontal cortex.A yoked-triad design (n = 8) was used. One rat controlled cocaine delivery and the other two passively received cocaine or saline. Rats controlling drug delivery (1.0 mg/kg) self-administered cocaine from either P37-P59 or P77-P99, and then underwent 18 drug-free days (P60-P77 vs. P100-P117). Rats next were tested for acquisition of odor-delayed win-shift behavior conducted over 15 sessions (P78-P96 vs. P118-P136).Cocaine self-administration did not differ between adults and adolescents. During the test phase of the odor-delayed win-shift task (relatively difficult task demands), rats from both drug-onset ages showed learning deficits. Rats with cocaine self-administration experience committed more errors and had longer session latencies compared to rats passively receiving saline or cocaine. Rats with adolescent-onset cocaine self-administration experience showed an additional learning deficit by requiring more sessions to reach criterion levels for task acquisition compared to same-aged passive saline controls or rats with adult-onset cocaine self-administration experience. Rats passively receiving cocaine did not differ from the passive saline control from either age group.Rats with adolescent-onset cocaine self-administration experience were more impaired in an orbitofrontal cortex-related learning task than rats with adult-onset cocaine self-administration experience. |
| Databáze: | OpenAIRE |
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