Efficacy of systemic and intratympanic corticosteroid combination therapy versus intratympanic or systemic therapy in patients with idiopathic sudden sensorineural hearing loss: a randomized controlled trial
| Autor: | Farzad Firouzi, Sasan Dabiri, Shahin Bastaninejad, Niloufar Saeedi, Hossein Ghazavi, Mohammadtaghi Khorsandi Ashtiani, Leyla Sahebi, Sevil Nasirmohtaram |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Combination therapy medicine.drug_class Hearing loss Administration Topical Hearing Loss Sensorineural Anti-Inflammatory Agents Administration Oral Placebo Antiviral Agents law.invention 03 medical and health sciences 0302 clinical medicine Audiometry Double-Blind Method Randomized controlled trial Adrenal Cortex Hormones law Internal medicine medicine Humans 030223 otorhinolaryngology medicine.diagnostic_test business.industry Proton Pump Inhibitors General Medicine Hearing Loss Sudden Middle Aged Treatment Outcome Otorhinolaryngology Concomitant Corticosteroid Drug Therapy Combination Female Pure tone audiometry medicine.symptom business 030217 neurology & neurosurgery Tinnitus Follow-Up Studies |
| Zdroj: | European Archives of Oto-Rhino-Laryngology. 275:89-97 |
| ISSN: | 1434-4726 0937-4477 |
| DOI: | 10.1007/s00405-017-4808-0 |
| Popis: | The present study was conducted to compare the rates of recovery from idiopathic sudden deafness after the treatment with oral and intratympanic corticosteroids in both mono and combination therapies. Triple-blind randomized clinical trial. Tertiary referral hospital. A total of 112 patients who were admitted to the ENT emergency department randomly divided into three groups: an oral corticosteroid plus intratympanic placebo (systemic corticosteroid monotherapy group); an intratympanic corticosteroid plus oral placebo group (IT monotherapy group); and a combination therapy group (IT plus systemic combination group). All patients were treated additionally with antiviral and proton pomp inhibitor. An audiometry was performed once before beginning the therapies and again at the end of the therapy. Of the total of 112 patients, 32 received intratympanic (IT) corticosteroids, 45 were receiving systemic corticosteroids, and 35 were receiving a combination of the two. A total of 74 patients (66.1%) responded positively [response to treatment was calculated as gain of at least 10 dB in 10 dB in average threshold or with the minimum improvement of 15% in speech discrimination scores (SDS)] to corticosteroid therapy. No significant differences were observed between the three groups (IT, systemic group, and combination therapy group) in their overall response to treatment (p = 0.5). Patients who suffered from concomitant tinnitus and dizziness responded less positively to the treatment (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink