Increased serum brain-derived neurotrophic factor and adrenocorticotropic hormone levels are associated with obsessive compulsive disorder in medication‑free children

Autor: Ayhan Bilgiç, Ömer Faruk Akça, Merve Sertdemir, Ibrahim Kilinc
Rok vydání: 2020
Předmět:
endocrine system
medicine.medical_specialty
Hypothalamo-Hypophyseal System
Obsessive-Compulsive Disorder
Adolescent
Pituitary-Adrenal System
Adrenocorticotropic hormone
03 medical and health sciences
0302 clinical medicine
Adrenocorticotropic Hormone
Neurotrophic factors
Internal medicine
Developmental and Educational Psychology
Glial cell line-derived neurotrophic factor
Medicine
Humans
0501 psychology and cognitive sciences
Child
Depression (differential diagnoses)
Brain-derived neurotrophic factor
biology
business.industry
Brain-Derived Neurotrophic Factor
05 social sciences
General Medicine
030227 psychiatry
Psychiatry and Mental health
Endocrinology
Nerve growth factor
nervous system
Pediatrics
Perinatology and Child Health
biology.protein
Anxiety
medicine.symptom
business
050104 developmental & child psychology
Neurotrophin
Zdroj: European childadolescent psychiatry. 31(2)
ISSN: 1435-165X
Popis: This study aimed to investigate serum levels of neurotrophins, including brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and neurotrophin-3 (NTF3), and hypothalamic–pituitary–adrenal axis (HPA) members including adrenocorticotropic hormone (ACTH) and cortisol in children with obsessive–compulsive disorder (OCD). The possible relationships between serum neurotrophins and HPA axis members were also addressed. A total of 60 medication-free children with OCD and 57 controls aged 8–18 years were enrolled in this study. The severity of OCD symptoms was determined by the Children’s Yale-Brown Obsessive Compulsive Scale. The severity of anxiety and depression symptoms were assessed by self-report inventories. The serum levels of neurotrophins, ACTH, and cortisol were measured using enzyme-linked immunosorbent assay kits. Serum BDNF levels were significantly higher in the OCD group than in the control group for either sex and for the whole sample. Compared to controls, serum ACTH levels were significantly higher in the OCD group for the whole sample. An analysis of covariance was also conducted for the whole sample and indicated that, while controlling the potential confounders, including body-mass index percentile, age, sex, and the severity of depression and anxiety, the results did not change. Strong negative correlations between BDNF, NGF and NTF3, and HPA axis members were determined in the patient group for either sex and for the whole sample. These findings suggest that dysregulations of BDNF and ACTH may be associated with childhood OCD. Furthermore, there may be inverse relationships between certain neurotrophins and HPA axis members in these patients.
Databáze: OpenAIRE
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