Increased serum levels of B cell activating factor (BAFF) in subsets of patients with idiopathic inflammatory myopathies
| Autor: | Heřman Mann, T Vallerskog, Jiri Vencovsky, Jaromir Belacek, S Barbasso Helmers, Ingrid E. Lundberg, I Putova, Olga Krystufkova, V Malmström, Christina Trollmo |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Tumor Necrosis Factor Ligand Superfamily Member 13 Immunology Polymyositis Dermatomyositis Statistics Nonparametric General Biochemistry Genetics and Molecular Biology Young Adult stomatognathic system Rheumatology immune system diseases Internal medicine B-Cell Activating Factor medicine Humans Immunology and Allergy Child skin and connective tissue diseases B-cell activating factor Creatine Kinase Glucocorticoids Myositis Aged Autoantibodies Analysis of Variance biology business.industry Autoantibody Middle Aged medicine.disease Connective tissue disease stomatognathic diseases C-Reactive Protein Endocrinology Antibodies Antinuclear Case-Control Studies biology.protein Female Inclusion body myositis Antibody business |
| Zdroj: | Annals of the Rheumatic Diseases. 68:836-843 |
| ISSN: | 0003-4967 |
| Popis: | To investigate serum levels of B cell activating factor (BAFF) in patients with myositis and correlate these to autoantibody profile, clinical phenotype and treatment.BAFF levels in sera from 49 patients with dermatomyositis, 44 with polymyositis, 6 with inclusion body myositis and 30 matched controls were measured by ELISA. Specific autoantibodies were detected by line blot and western blot assays.Serum levels of BAFF were significantly higher in patients compared to healthy controls (p = 0.003). Patients with anti-Jo-1 autoantibodies had higher BAFF levels than control individuals (p0.003) or patients without any specific autoantibodies (p0.05). Patients with dermatomyositis had higher BAFF levels compared to polymyositis (p0.05). Patients with interstitial lung disease (ILD) had higher BAFF levels than patients without ILD (p0.05) or controls (p0.01) but this could be explained by presence of anti-Jo-1 autoantibodies. BAFF levels correlated with serum creatine kinase (CK) (rs = 0.365, p = 0.0005) but not with C-reactive protein (CRP) levels. A negative correlation of BAFF levels with glucocorticoid daily dose for all patients (rs = -0.292, p = 0.003) and with cumulative glucocorticoid doses in early myositis cases (rs = -0.659, p0.001) was recorded.Our finding of elevated serum levels of BAFF in patients with myositis with described phenotypes together with the correlations between levels of BAFF and CK and a negative correlation with dose of glucocorticoids, indicate that BAFF could be a potential therapeutic target in such cases. |
| Databáze: | OpenAIRE |
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