Summary statistics for drug concentrations in post‐mortem femoral blood representing all causes of death

Autor: Ilkka Ojanperä, Raimo A. Ketola
Přispěvatelé: Department of Forensic Medicine
Rok vydání: 2019
Předmět:
Male
post-mortem drug redistribution
PHARMACOKINETICS
Percentile
116 Chemical sciences
GAS-CHROMATOGRAPHY
Pharmaceutical Science
Autopsy
METABOLITES
01 natural sciences
BUPRENORPHINE
Analytical Chemistry
cause of death
0302 clinical medicine
BENZODIAZEPINES
Diagnosis
Blood alcohol
Medicine
HUMAN PLASMA
Spectroscopy
Cause of death
media_common
Poisoning
319 Forensic science and other medical sciences
Venous blood
Middle Aged
3. Good health
Pharmaceutical Preparations
317 Pharmacy
drug concentration
Blood Alcohol Content
Female
Drug
medicine.medical_specialty
media_common.quotation_subject
POISONINGS
Post mortem blood
Forensic Toxicology
03 medical and health sciences
Pharmacokinetics
Internal medicine
Humans
VOLUNTEERS
Environmental Chemistry
030216 legal & forensic medicine
LC-MS/MS
business.industry
post-mortem blood
010401 analytical chemistry
post-mortem toxicology
0104 chemical sciences
1182 Biochemistry
cell and molecular biology
COMPILATION
Drug Overdose
business
Zdroj: Drug Testing and Analysis. 11:1326-1337
ISSN: 1942-7611
1942-7603
Popis: Concentration distributions for 183 drugs and metabolites frequently found in post-mortem (PM) femoral venous blood were statistically characterized based on an extensive database of 122 234 autopsy cases investigated during an 18-year period in a centralized laboratory. The cases represented all causes of death, with fatal drug poisonings accounting for 8%. The proportion of males was 74% with a median age of 58 years compared with 26% females with a median age of 64 years. In 36% of these cases, blood alcohol concentration was higher than or equal to 0.2 parts per thousand, the median being 1.6 parts per thousand. The mean, median, and upper percentile (90th, 95th, 97.5th) drug concentrations were established, as the median PM concentrations give an idea of the "normal" PM concentration level, and the upper percentile concentrations indicate possible overdose levels. A correspondence was found between subsets of the present and the previously published PM drug concentrations from another laboratory that grouped cases according to the cause of death. Our results add to the knowledge for evidence-based interpretation of drug-related deaths.
Databáze: OpenAIRE
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