Summary statistics for drug concentrations in post‐mortem femoral blood representing all causes of death
Autor: | Ilkka Ojanperä, Raimo A. Ketola |
---|---|
Přispěvatelé: | Department of Forensic Medicine |
Rok vydání: | 2019 |
Předmět: |
Male
post-mortem drug redistribution PHARMACOKINETICS Percentile 116 Chemical sciences GAS-CHROMATOGRAPHY Pharmaceutical Science Autopsy METABOLITES 01 natural sciences BUPRENORPHINE Analytical Chemistry cause of death 0302 clinical medicine BENZODIAZEPINES Diagnosis Blood alcohol Medicine HUMAN PLASMA Spectroscopy Cause of death media_common Poisoning 319 Forensic science and other medical sciences Venous blood Middle Aged 3. Good health Pharmaceutical Preparations 317 Pharmacy drug concentration Blood Alcohol Content Female Drug medicine.medical_specialty media_common.quotation_subject POISONINGS Post mortem blood Forensic Toxicology 03 medical and health sciences Pharmacokinetics Internal medicine Humans VOLUNTEERS Environmental Chemistry 030216 legal & forensic medicine LC-MS/MS business.industry post-mortem blood 010401 analytical chemistry post-mortem toxicology 0104 chemical sciences 1182 Biochemistry cell and molecular biology COMPILATION Drug Overdose business |
Zdroj: | Drug Testing and Analysis. 11:1326-1337 |
ISSN: | 1942-7611 1942-7603 |
Popis: | Concentration distributions for 183 drugs and metabolites frequently found in post-mortem (PM) femoral venous blood were statistically characterized based on an extensive database of 122 234 autopsy cases investigated during an 18-year period in a centralized laboratory. The cases represented all causes of death, with fatal drug poisonings accounting for 8%. The proportion of males was 74% with a median age of 58 years compared with 26% females with a median age of 64 years. In 36% of these cases, blood alcohol concentration was higher than or equal to 0.2 parts per thousand, the median being 1.6 parts per thousand. The mean, median, and upper percentile (90th, 95th, 97.5th) drug concentrations were established, as the median PM concentrations give an idea of the "normal" PM concentration level, and the upper percentile concentrations indicate possible overdose levels. A correspondence was found between subsets of the present and the previously published PM drug concentrations from another laboratory that grouped cases according to the cause of death. Our results add to the knowledge for evidence-based interpretation of drug-related deaths. |
Databáze: | OpenAIRE |
Externí odkaz: |