Regenerative application of stromal vascular fraction cells enhanced fat graft maintenance: clinical assessment in face rejuvenation
| Autor: | Domenico De Fazio, Angelo Trivisonno, Simone Garcovich, Claudio Calabrese, Barbara De Angelis, Aris Sterodimas, Jacopo Pizzicannella, Pietro Gentile, Laura Dionisi |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Pathology medicine.medical_specialty Clinical Biochemistry Adipose-derived Stromal Vascular Fraction Cells Cohort Studies Young Adult face rejuvenation fat graft 03 medical and health sciences 0302 clinical medicine Drug Discovery Female patient Humans Rejuvenation Medicine Fat graft Aged Retrospective Studies SVFs Pharmacology business.industry Graft Survival Settore MED/19 Middle Aged Plastic Surgery Procedures Stromal vascular fraction 030104 developmental biology Adipose Tissue Patient Satisfaction Face 030220 oncology & carcinogenesis Rhytidoplasty Adipose-derived stromal vascular fraction cells Female Stromal Cells Settore MED/35 - MALATTIE CUTANEE E VENEREE business |
| Zdroj: | Expert Opinion on Biological Therapy. 20:1503-1513 |
| ISSN: | 1744-7682 1471-2598 |
| DOI: | 10.1080/14712598.2020.1815703 |
| Popis: | The aim of this study was to evaluate the safety and efficacy of the use of FG-SVFs in face rejuvenation for esthetic improvement.33 female patients affected by face's soft-tissue defects with loss of volume, study group (SG), were treated with FG-SVFs, comparing results with a control group (CG) (n = 30) treated with fat graft not enhanced (FG). Clinical evaluation, a photographic assessment, magnetic resonance imaging (MRI), and ultrasound (US) were performed. Post-operative follow-up was performed at 1, 3, 7, 12, 24, 48, weeks, and then annually.SG patients showed 61% maintenance of the contour restoring and of volume after 3 years compared with the CG treated with FG, who showed 31% maintenance. 60.7% (n = 20) of SG patients, presented an increase of 6.6 mm in the soft tissue volume after 36 months, which was reported in only 33,3% (n = 10) of the CG. Volumetric persistence in the SG was higher than that in the CG (p. 0001 vs. CG). MRI and US moreover confirmed the absence of important side effects, as fat necrosis, and cytosteatonecrotic areas.The use of FG-SVFs was safe and effective in this series of a case treated. |
| Databáze: | OpenAIRE |
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