The after-hours circadian mutant has reduced phenotypic plasticity in behaviors at multiple timescales and in sleep homeostasis
| Autor: | Glenda Lassi, Edoardo Balzani, Silvia Maggi, Patrick M. Nolan, Liudmila Mus, Andrea Plano, Valter Tucci, Federico Tinarelli, Raul R. Gainetdinov, Thierry Nieus, Celina Garcia-Garcia, Stefano Espinoza, Fuat Balcı |
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| Přispěvatelé: | Balcı, Fuat (ORCID 0000-0003-3390-9352 & YÖK ID 51269), Maggi, Silvia, Balzani, Edoardo, Lassi, Glenda, Garcia-Garcia, Celina, Plano, Andrea, Espinoza, Stefano, Mus, Liudmila, Tinarelli, Federico, Nolan, Patrick M., Gainetdinov, Raul R., Nieus, Thierry, Tucci, Valter, College of Social Sciences and Humanities, Department of Psychology |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Period (gene) Circadian clock lcsh:Medicine Gene-expression Period Mice Reveals Rhythms Disease Protein Mouse Fbxl3 Time Biology Multidisciplinary sciences Article 03 medical and health sciences 0302 clinical medicine Circadian Clocks Animals Homeostasis Circadian rhythm Effects of sleep deprivation on cognitive performance lcsh:Science Phenotypic plasticity Mice Inbred BALB C Mice Inbred C3H Multidisciplinary Behavior Animal lcsh:R Brain Cognition Sleep in non-human animals Adaptation Physiological Circadian Rhythm Mice Inbred C57BL 030104 developmental biology Mutation lcsh:Q Female Adaptation Sleep Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Maggi, S, Balzani, E, Lassi, G, Garcia-Garcia, C, Plano, A, Espinoza, S, Mus, L, Tinarelli, F, Nolan, P M, Gainetdinov, R R, Balci, F, Nieus, T & Tucci, V 2017, ' The after-hours circadian mutant has reduced phenotypic plasticity in behaviors at multiple timescales and in sleep homeostasis ', Scientific Reports, vol. 7, no. 1, 17765 . https://doi.org/10.1038/s41598-017-18130-2 Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017) |
| Popis: | Circadian clock is known to adapt to environmental changes and can significantly influence cognitive and physiological functions. In this work, we report specific behavioral, cognitive, and sleep homeostatic defects in the after hours (Afh) circadian mouse mutant, which is characterized by lengthened circadian period. We found that the circadian timing irregularities in Afh mice resulted in higher interval timing uncertainty and suboptimal decisions due to incapability of processing probabilities. Our phenotypic observations further suggested that Afh mutants failed to exhibit the necessary phenotypic plasticity for adapting to temporal changes at multiple time scales (seconds-to-minutes to circadian). These behavioral effects of Afh mutation were complemented by the specific disruption of the Per/Cry circadian regulatory complex in brain regions that govern food anticipatory behaviors, sleep, and timing. We derive statistical predictions, which indicate that circadian clock and sleep are complementary processes in controlling behavioral/cognitive performance during 24 hrs. The results of this study have pivotal implications for understanding how the circadian clock modulates sleep and behavior. Russian Science Foundation |
| Databáze: | OpenAIRE |
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