Hydrolysis of Oxaliplatin—Evaluation of the Acid Dissociation Constant for the Oxalato Monodentate Complex
| Autor: | Staffan Eksborg, Elin Jerremalm, Hans Ehrsson |
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| Rok vydání: | 2003 |
| Předmět: |
Denticity
Organoplatinum Compounds Chemistry Hydrolysis Inorganic chemistry Temperature Pharmaceutical Science chemistry.chemical_element Antineoplastic Agents Alkaline hydrolysis (body disposal) Medicinal chemistry digestive system diseases Acid dissociation constant Oxaliplatin Dissociation constant Kinetics Reaction rate constant Solubility medicine Platinum Algorithms medicine.drug |
| Zdroj: | Journal of Pharmaceutical Sciences. 92:436-438 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.10306 |
| Popis: | Alkaline hydrolysis of the platinum anticancer drug oxaliplatin gives the oxalato monodentate complex and the dihydrated oxaliplatin complex in two consecutive steps. The acid dissociation constant for the oxalato monodentate intermediate was determined by a kinetic approach. The p K a value was estimated as 7.23. The monodentate intermediate is assumed to rapidly react with endogenous compounds, resulting in a continuous conversion of oxaliplatin via the monodentate form. |
| Databáze: | OpenAIRE |
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