Adjuvant radiotherapy in stage 1 seminoma: Evaluation of prognostic factors and results of survival
| Autor: | Ozlem Aynaci, Asli Sahbaz, Lasif Serdar, Emine Canyilmaz, Gulsen Soydemir, Yahyahan Memis, Adnan Yoney, Turkan Ozturk Topcu, Zumrut Bahat, Mustafa Kandaz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Gastroenterology lcsh:RC254-282 Dog-leg field Young Adult Internal medicine Medicine Humans Radiology Nuclear Medicine and imaging Orchiectomy Stage (cooking) Survival rate Testicular cancer radiotherapy Aged Neoplasm Staging Inguinal orchiectomy Univariate analysis business.industry dose General Medicine Seminoma Middle Aged medicine.disease Prognosis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Surgery Tumor Burden testicular cancer Radiation therapy Survival Rate Treatment Outcome Oncology Radiotherapy Adjuvant Neoplasm Recurrence Local business paraaortic field seminom Follow-Up Studies |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 11, Iss 2, Pp 313-318 (2015) |
| ISSN: | 1998-4138 0973-1482 |
| Popis: | Purpose: The purpose of this study was to evaluate the prognostic factors affecting overall survival (OS), cause-specific survival (CSS), progression-free survival (PFS), and survival among patients undergoing adjuvant radiotherapy (RT) for stage-1 seminoma. Materials and Methods: Between August 1997 and May 2013, 68 patients diagnosed with stage-1 seminoma were retrospectively evaluated. The median age was 39 (24-74) years. All patients received adjuvant RT after inguinal orchiectomy. Fifty-eight (85.3%) patients received paraaortic RT; 10 (14.7%) received dog-leg field RT. The median RT dose was 23.4 (23.4-30.6) Gy. Results: The median follow-up period was 77.5 (6.7-198.5) months. During the follow-up period, two patients developed distant metastasis, and none developed local recurrence. Two patients died from seminoma, and three died for other reasons. The 5, 10, and 15-year OS rates were 94.7%, 89.6%, and 89.6%, respectively. The 5, 10, and 15-year CSS rates were 98.5%, 96%, and 96%, respectively. The 5, 10, and 15-year PFS rate was 96.1%. The univariate analysis showed that only histological subtype was significant for OS. The 10-year survival rate was 100% among patients with seminoma histology, 90.8% among patients with a classic seminoma histology, and 50% among patients with an anaplastic seminoma histology (P < 0.001). A multivariate analysis showed that the anaplastic seminoma was a negative prognostic indicator for OS (P = 0.042). Conclusion: Adjuvant RT resulted in excellent long-term survival and local control in patients with stage-1 seminoma after orchiectomy. During a short follow-up, secondary malignancy (SM) and late cardiovascular morbidity were not observed. Despite those results, concern of SM and late cardiovascular morbidity remains. |
| Databáze: | OpenAIRE |
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