The role of laboratory processing in determining diagnostic conclusiveness of breast fine needle aspirations: conventional smearing versus a monolayer preparation
| Autor: | Bauke W. Kooistra, C.A.P. Wauters, L.J.A. Strobbe |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Suspicious for Malignancy medicine.diagnostic_test business.industry CYTOCENTRIFUGE Biopsy Fine-Needle Anatomical pathology Breast Neoplasms General Medicine Middle Aged Pathology and Forensic Medicine Fine-needle aspiration Medicine Humans Female Radiology Breast Ultrasonography Mammary Medical diagnosis business Reference standards Ultrasonography Interventional Aged Retrospective Studies |
| Zdroj: | Journal of clinical pathology. 62(10) |
| ISSN: | 1472-4146 |
| Popis: | Aim:To compare breast fine needle aspiration (FNA) specimens prepared by conventional smearing (CS) versus monolayer preparation (MP), with respect to the conclusiveness of the cytopathological diagnosis.Methods:From 1992 to 1996, aspirators prepared aspirates themselves by direct smearing onto 2–4 slides. From 1999 to 2003, aspirate preparation was performed in the laboratory, creating a MP, using a Hettich cytocentrifuge. FNA diagnoses were categorised into inadequate (C1), benign (C2), atypical (C3), suspicious for malignancy (C4) and malignant (C5). The reference standard constituted histological follow-up. A conclusive FNA diagnosis was defined as C2 in lesions benign on follow-up and C5 in lesions malignant on histology.Results:From 1992 to 1996, 692 aspirates were processed by CS, whereas from 1999 to 2003, 1301 aspirates were processed by MP. More FNA were ultrasound-guided in the MP group (85.6% versus 21.5%, pConclusion:Patients presenting with breast lesions can more often be offered a same-day, conclusive cytopathological diagnosis when FNA are prepared by a manual MP processing technique. |
| Databáze: | OpenAIRE |
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